Tumor Cell Membrane‐Camouflaged Vortex Magnetic Nanoannulars Programmed by Low‐Frequency Magnetic Field: A Novel Anti‐Cancer Delivery System in Triple‐Negative Breast Cancer

• Published in: Advanced functional materials 2024-10, Vol.34 (42), p.n/a
• Main Authors: Lu, Yunshu, Gu, Fenfen, Ma, Yuwei, Da, Xianhong, Li, Ruonan, Jiang, Lan, Li, Xiang, Liu, Yan
• Format: Article
• Language: English
• Subjects: Breast cancer; Cell cycle; Cell membranes; Chemotherapy; Doxorubicin; Fe3O4 vortex nanoannulars; ferroptosis; Gene sequencing; Iron oxides; low‐frequency time‐varying magnetic field; Magnetic fields; nanomedicine; Nanoparticles; triple‐negative breast cancer; Tumors
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.202401940

Triple‐negative breast cancer (TNBC), a highly aggressive form of breast cancer, currently lacks targeted therapies and is associated with high recurrence rates in medical practice. In this study, the effectiveness of a specially developed magnetic nanodrug, namely doxorubicin (DOX)‐loaded Fe3O4 vortex magnetic nanoannulars coated with a cancer cell membrane (DOX‐VMAs@CM), against cancer under a varying low‐frequency magnetic field (MF), is investigated. This advanced nanodrug can specifically target and accumulate in tumors. Additionally, it considerably improves tumor suppression compared with that of DOX chemotherapy alone, indicating the possibility of homologous targeting of the cancer cell membrane and the vibrating effect of the MF. The DOX‐VMAs@CM nanoparticles (NPs) exhibit exceptional safety characteristics because of their ability to specifically target tumors. The results of RNA sequencing suggest that the potential mechanisms may involve cellular respiration, cell cycle, and ferroptosis regulation. Altogether, chemotherapy is successfully optimized by implementing a delivery system and MF intervention, and the developed DOX‐VMAs@CM NPs hold significant potential for use in the clinical treatment of TNBC. Herein, a magnetic nanodrug based on doxorubicin‐loading Fe3O4 vortex nanoannulars and coated with a cancer cell membrane, which works under a low‐frequency time‐varying magnetic field, is engineered. It shows excellent tumor targeting, tumor killing, and safety profiles. Potential mechanisms include regulation of cell respiration, cell cycle, and ferroptosis. The present study shows a promising clinical application potential for triple‐negative breast cancer therapy.