Structurally Divergent Synthesis of Azetidines, 5,6‐Dihydro‐1,3‐oxazines and 2,3‐Dihydro‐1,4‐oxazines through Palladium‐Catalyzed Tandem Allylic Substitution Reaction

Comprehensive Summary A regiodivergent synthesis of azetidines, 5,6‐dihydro‐1,3‐oxazines and 2,3‐dihydro‐1,4‐oxazines has been achieved through palladium‐catalyzed tandem allylic substitution reaction. This protocol provides a variety of heterocycles in satisfactory yields with good to excellent reg...

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Bibliographic Details
Published in:Chinese journal of chemistry 2024-11, Vol.42 (22), p.2773-2778
Main Authors: Meng, Ru‐Fang, Kong, Yu‐Juan, Wu, Xiao‐Yan, Zhang, Huan, Wang, Wei, Liang, Wen‐Jie, Zheng, Lan, Lin, Chenxiang, Su, Wei, Xiao, Jun‐An
Format: Article
Language:English
Subjects:
Allylic dicarbonate
Allylic substitution
Annulation
Azetidine
Chemical synthesis
Domino reactions
Palladium
Palladium catalysis
Regioselectivity
Substitution reactions
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Summary:Comprehensive Summary A regiodivergent synthesis of azetidines, 5,6‐dihydro‐1,3‐oxazines and 2,3‐dihydro‐1,4‐oxazines has been achieved through palladium‐catalyzed tandem allylic substitution reaction. This protocol provides a variety of heterocycles in satisfactory yields with good to excellent regioselectivities under mild reaction conditions. A regiodivergent synthesis of azetidines, 5,6‐dihydro‐1,3‐oxazines and 2,3‐dihydro‐1,4‐oxazines has been achieved through palladium‐catalyzed tandem allylic substitution reaction. This protocol provides a variety of heterocycles in satisfactory yields with good to excellent regioselectivities under mild reaction conditions.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.202400533