Study of the Modifying Effect of 1-β-D-Arabinofuranosyl Cytosine on the Immune Status of Rats in the Long Period under the Exposure to Protons

• Published in: Physics of particles and nuclei letters 2024-10, Vol.21 (5), p.1093-1097
• Main Authors: Pronskikh, E. V., Kolesnikova, I. A., Severiukhin, Yu. S., Utina, D. M., Golikova, K. N., Khramko, T. S., Lalcovicova, M., Molokanov, A. G.
• Format: Article
• Language: English
• Subjects: Counting; Ecology and Nuclear Medicine; Ionizing radiation; Leukocytes; Parameter modification; Particle and Nuclear Physics; Physics; Physics and Astronomy; Physiological effects; Protons; Radiobiology; Spleen; Visual observation; Weight
• ISSN: 1547-4771; 1531-8567
• DOI: 10.1134/S1547477124701632

The effect of the combined use of protons at a dose of 3 Gy and 1-β-D-arabinofuranosylcytosine (Ara-C) on the physiological parameters of immunocompetent organs on the 90th day was studied: the weight of the spleen, thymus, total leukocyte count, and leukogram were examined. A significant decrease in thymus mass was established under the combined action of protons and Ara-C; a trend was observed in all experimental groups towards a decrease in spleen weight compared to the reference group. A statistically significant increase in the number of leukocytes in the “Ara-C” group was revealed, without differences in their types distribution during visual differentiated counting. It is concluded that further research of combined use of the DNA replication and Ara-C repair inhibitor and various types of ionizing radiation may be a promising way for extending the therapeutic capabilities of oncological practice.