Metal‐Catalyzed Coupling of N‐Tosylhydrazones with Compounds Containing C−H/Heteroatom‐H Bonds

• Published in: Asian journal of organic chemistry 2024-09, Vol.13 (9), p.n/a
• Main Authors: Akanksha, Singh, Ajaya K., Asthana, Anupama, Ravi, Rangnath, Kishor Jha, Abadh
• Format: Article
• Language: English
• Subjects: Alkylation; carbene migratory insertion; Carbon; Cascade chemical reactions; Chemical bonds; Chemical synthesis; Copper; cross-coupling; C−H functionalization; diazo compound; hetero-H activation; Palladium; Transition metals
• ISSN: 2193-5807; 2193-5815
• DOI: 10.1002/ajoc.202400232

The present review covers various advances in the field of metal‐catalyzed coupling of N‐tosylhydrazones with compounds containing C−H/heteroatom‐H bonds, including transition metal catalysts i. e., Pd, Rh, Cu, Ag, Ni and Co and resulting alkylated, alkenylated, alkynylated, allenylated, annulated and many other products. A metal carbene migratory insertion process play a key role in carbon‐carbon single bond (C−C) and carbon‐carbon double bond (C=C) formation and undergoes variety of cascade reactions to synthesize a wide scope of pharmaceutically and medicinally valuable scaffoldings. This review covers various advances in the field of metal‐catalyzed coupling of N‐tosylhydrazones with compounds containing C−H/heteroatom‐H bonds. The metal catalyst used, includes Pd, Rh, Cu, Ag, Ni and Co and resulting in formation of alkylated, alkenylated, alkynylated, allenylated, annulated and many other products. The synthesized products have a wide pharmaceutical and medicinal importance.