Neuroleptic malignant syndrome during low dosed neuroleptic medication in first-episode psychosis : a case report

Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal side-effect of antipsychotic drug therapy, especially of dopamine receptor antagonists. As a dose relationship has been postulated, low dose neuroleptization would be expected to help to avoid this side-effect. In contrast, we repo...

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Bibliographic Details
Published in:Psychopharmacologia 1999-06, Vol.144 (4), p.416-418
Main Authors: GÖNNER, F, BAUMGARTNER, R, SCHÜPBACH, D, MERLO, M. C. G
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - adverse effects
Antipsychotics
Biological and medical sciences
Clozapine
Clozapine - therapeutic use
Dantrolene - therapeutic use
Drug therapy
Drug toxicity and drugs side effects treatment
Female
Fluphenazine
Fluphenazine - administration & dosage
Fluphenazine - adverse effects
Humans
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Muscle Relaxants, Central - therapeutic use
Neuroleptic Malignant Syndrome - drug therapy
Neuroleptic Malignant Syndrome - etiology
Pharmacology. Drug treatments
Psychopathology
Psychosis
Psychotic Disorders - drug therapy
Remission
Side effects
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Summary:Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal side-effect of antipsychotic drug therapy, especially of dopamine receptor antagonists. As a dose relationship has been postulated, low dose neuroleptization would be expected to help to avoid this side-effect. In contrast, we report on a 21-year-old female following low dose fluphenazine treatment with 2.5 mg/day. The patient recovered from NMS after 3 days of dantrolene administration. Eventually, remission from psychotic symptoms was achieved with clozapine. At 8-month follow-up, psychopathology remained stable and there were no more signs of NMS.
ISSN:0033-3158
1432-2072
DOI:10.1007/s002130051026