Short-term treatment with citicoline (CDP-choline) attenuates some measures of craving in cocaine-dependent subjects : a preliminary report

The administration of cytidine-5'-diphosphate choline (CDP-choline, citicoline) to animals increases the rate of membrane phospholipid synthesis and elevates brain dopamine levels. Because cocaine dependence has been associated with increases in brain phospholipid precursors, as well as depleti...

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Bibliographic Details
Published in:Psychopharmacologia 1999-02, Vol.142 (2), p.132-138
Main Authors: RENSHAW, P. F, DANIELS, S, LUNDAHL, L. H, ROGERS, V, LUKAS, S. E
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blindness
Central nervous system
Central Nervous System - drug effects
Central Nervous System - physiology
Choline
Citicoline
Cocaine
Cocaine-Related Disorders - drug therapy
Cocaine-Related Disorders - urine
Cues
Cytidine Diphosphate Choline - adverse effects
Cytidine Diphosphate Choline - therapeutic use
Cytidine Diphosphate Choline - urine
Dopamine
Double-Blind Method
Drug abuse
Drug addiction
Drug addictions
Female
Humans
Male
Medical sciences
Mood
Nootropic Agents - adverse effects
Nootropic Agents - therapeutic use
Nootropic Agents - urine
Phospholipids
Side effects
Task Performance and Analysis
Toxicology
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Summary:The administration of cytidine-5'-diphosphate choline (CDP-choline, citicoline) to animals increases the rate of membrane phospholipid synthesis and elevates brain dopamine levels. Because cocaine dependence has been associated with increases in brain phospholipid precursors, as well as depletion of dopamine within the central nervous system, the present outpatient study was conducted to assess the safety of citicoline (500 mg bid) and to determine if short-term treatment alters mood states and cocaine craving in subjects with a history of cocaine dependence. In addition, measures of drug craving and mood states after presentation of cocaine-related cues were collected on two occasions: before and after 14 days of double-blind treatment with either citicoline or placebo. Subjects did not experience any side effects and citicoline treatment was associated with decreases in self-reported mood states associated with cocaine craving. These preliminary data are encouraging and suggest that citicoline warrants further study as a promising potential treatment for cocaine abuse and dependence that is devoid of side effects.
ISSN:0033-3158
1432-2072
DOI:10.1007/s002130050871