Enzyme free highly sensitive glucose biosensor based on Ag/Cu2O nanostructures deposited on TiO2 nanotube arrays

A highly sensitive non-enzymatic biosensor based on a deposition of silver nanoparticles with Cu 2 O on TiO 2 nanotube arrays has been developed for the detection of glucose. The TiO 2 nanotubes (TNTs) were fabricated by anodization on a thin plate Ti6Al4V titanium alloy. Subsequently, Cu 2 O was de...

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Bibliographic Details
Published in:Monatshefte für Chemie 2024-11, Vol.155 (11), p.1095-1107
Main Authors: Kumar, Bittu, Sinha, Sudip Kumar
Format: Article
Language:English
Subjects:
Analytical Chemistry
Anodizing baths
Arrays
Biosensors
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Copper oxides
Crystal structure
Deposition
Electrical measurement
Electrochemical analysis
Electrochemical impedance spectroscopy
Electron microscopy
Electron transfer
Electrons
Field emission microscopy
Glucose
Inorganic Chemistry
Microscopy
Nanomaterials
Nanostructure
Nanotubes
Organic Chemistry
Original Paper
Physical Chemistry
Plating baths
Real time
Silver
Theoretical and Computational Chemistry
Thin plates
Titanium alloys
Titanium base alloys
Titanium dioxide
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Summary:A highly sensitive non-enzymatic biosensor based on a deposition of silver nanoparticles with Cu 2 O on TiO 2 nanotube arrays has been developed for the detection of glucose. The TiO 2 nanotubes (TNTs) were fabricated by anodization on a thin plate Ti6Al4V titanium alloy. Subsequently, Cu 2 O was deposited on the TNTs using the wet chemical bath deposition method, followed by the electro-deposition of Ag nanomaterials. The crystal structure, phases, and morphology of the nanostructure (Ag-Cu 2 O@TiO 2 ) were examined using energy-dispersive X-ray, transmission electron microscopy, and field emission scanning electron microscopy. The addition of Cu 2 O and Ag to TNTs enhances the electroactive surface area, which results in a faster rate of electron transfer. The electrochemical behavior of Ag-Cu 2 O@TiO 2 was investigated using cyclic voltammetry, electrochemical impedance spectroscopy, and amperometry techniques. The Ag-Cu 2 O@TiO 2 exhibited a high level of sensitivity (1010.20 μA mM −1  cm −2 ), low detection limit of 36 µM, and a rapid response time (2 s). Furthermore, the real-time analysis of glucose in human blood serum demonstrated a high level of accuracy. This work illustrates the deposition of Ag-Cu 2 O on TNTs for fabrication of excellent selectivity, reproducibility, and remarkable stability. Graphical abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-024-03258-5