Copper and Photocatalytic Synergistic Strategies for Radical Cyclization Reactions

The rapid development of photo‐synergistic transition metal catalytic systems has provided a green paradigm to complement thermal transition metal catalytic methods. However, the most commonly used iridium or ruthenium complexes involve expensive in nature, in contrast to the abundant copper element...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2024-10, Vol.366 (19), p.4000-4016
Main Authors: Lu, Yue‐Jiao, Dai, Nan‐Nan, Li, Mu‐Han, Tian, Wen‐Chan, Li, Qiang, Wang, Zheng‐Jun, Tang, Keqi, Wei, Wen‐Ting
Format: Article
Language:English
Subjects:
Chemical reactions
Chemical synthesis
Copper
Copper and photocatalytic
Copper compounds
Cyclization
Electronic structure
Iridium
Light sources
Natural products
Organic transformations
Photocatalysis
Radical chemistry
Ruthenium compounds
Transition metals
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Summary:The rapid development of photo‐synergistic transition metal catalytic systems has provided a green paradigm to complement thermal transition metal catalytic methods. However, the most commonly used iridium or ruthenium complexes involve expensive in nature, in contrast to the abundant copper elements in the earth's crust, which are highly valued for their unique electronic structure and light‐absorbing properties. Recently, the application of copper and photocatalytic synergistic strategies in radical cyclization reactions has progressed considerably, leading to a renaissance in the synthesis of functional natural products, drugs and their analogues, but summary work addressing this aspect has not been reported. In this review, we briefly analyze the effect of ligand choice on copper complexes and some inorganic copper salts and even on light sources. We then summarize the copper and photocatalytic synergistic strategies in radical cyclization reactions and classify them into three categories, C, N and O radicals, according to the class of the central atom of the radical in each work, and in each category will be elaborated in turn from coordination cyclization via Cu catalysts, direct radical cyclization and other cyclization mode. For individual more complex reactions, the mechanisms are explored and briefly discussed.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202400665