Synthesis of Enamides through Hydro‐Functionalization of Ynamides

• Published in: European journal of organic chemistry 2024-10, Vol.27 (40), p.n/a
• Main Authors: Mishra, Archana, Sekhar Pati, Subhransu, Das, Jaya Prakash
• Format: Article
• Language: English
• Subjects: Chemical bonds; Chemical synthesis; Enamide; Hydrofunctionalization; Hydrohalogenation; Keteniminium; Ynamide
• ISSN: 1434-193X; 1099-0690
• DOI: 10.1002/ejoc.202400637

Most of the methods for the synthesis of functionalized enamides from ynamides were developed in the last two decades showing the contemporary interest in the exploration of ynamide chemistry. The utilization of the intrinsic reactivity of the ynamide triple bond through keteniminium intermediacy, coordination with metals, and as a radical acceptor toward the development of strategies for the synthesis of functionalized enamides reflect the constant strive and creativity in the design and execution of synthetic methods. The present review summarizes the synthetic strategies developed during the last two decades and is divided into the sections depending on the type of hydrofunctionalization reaction. It may be predicted that this field of chemistry will continue to grow exponentially in the coming years and the ready availability of a wide range of ynamides now provides an excellent opportunity to further enrich mainstream synthetic methodologies. The emergence of functionalized enamides as versatile synthetic intermediates reflects the constant strive and creativity in the design and execution of synthetic methods and contemporary interest in the exploration of ynamide chemistry. In this review, important developments in the hydrofunctionalization of ynamides toward the formation of functionalized enamides have been highlighted.