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Alkylation of azoles with alkenes catalyzed by the NiCl2Py2/IMes • HCl/ButONa system

A new approach to the alkylation of azoles with alkenes catalyzed by the nickel complexes with N-heterocyclic carbenes (Ni/NHC) was developed. The catalytically active Ni/NHC complexes are formed in situ from the air-stable precursors: the nickel chloride complex with pyridine (NiCl 2 Py 2 ), imidaz...

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Bibliographic Details
Published in:Russian chemical bulletin 2024-09, Vol.73 (9), p.2680-2686
Main Authors: Khazipov, O. V., Chernyshev, V. M.
Format: Article
Language:English
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Summary:A new approach to the alkylation of azoles with alkenes catalyzed by the nickel complexes with N-heterocyclic carbenes (Ni/NHC) was developed. The catalytically active Ni/NHC complexes are formed in situ from the air-stable precursors: the nickel chloride complex with pyridine (NiCl 2 Py 2 ), imidazolium salt IMes•HCl (IMes is 1,3-bis(2,4,6-trimethylphenyl)-1,3-dihydro-2 H -imidazol-2-ylidene) as the carbene source, and sodium tert -butoxide (Bu t ONa). The advantages of the developed approach are availability of the components of the catalytic system, no necessity to apply special agents for the reduction of Ni II to Ni 0 , and simplification of the synthesis procedure.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-024-4380-x