Radiobiological evaluation of hypo-fractionated breast cancer radiotherapy regimens in comparison with conventional approaches

Purpose:This study compares tumor control probability (TCP) and normal tissue complication probability (NTCP) across different hypo-fractionated (HypoRT) and conventional breast radiotherapy regimens using radiobiological models.Materials and methods:Computed tomography data from 30 patients with le...

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Bibliographic Details
Published in:Journal of radiotherapy in practice 2024-01, Vol.23, Article e23
Main Authors: Arjmand, Bahare, Chegeni, Nahid, Danyaei, Amir, Bagheri, Ali, Razzaghi, Samira, Rasouli, Naser, Karimi, Arezoo, Saki-Malehi, Amal, Hazbavi, Maryam, Mahmoudi, Farshid
Format: Article
Language:English
Subjects:
Breast cancer
Cancer therapies
Clinical trials
Computed tomography
Lungs
Oncology
Original Article
Patients
Planning
Probability
Radiation therapy
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Summary:Purpose:This study compares tumor control probability (TCP) and normal tissue complication probability (NTCP) across different hypo-fractionated (HypoRT) and conventional breast radiotherapy regimens using radiobiological models.Materials and methods:Computed tomography data from 30 patients with left breast-conserving surgery were used to evaluate three HypoRT regimens (39 Gy and 41·6 Gy in 13 fractions, and 40 Gy in 15 fractions) and a conventional regimen (50 Gy in 25 fractions). Dose-volume histograms (DVHs) were extracted for radiobiological calculations using Equivalent Uniform Dose (EUD) and Poisson models for TCP, and EUD and LKB (Lyman-Kutcher-Burman) models for NTCP.Results:Conventional treatment achieved significantly higher TCP (95%) than all HypoRT regimens (p < 0·001), with no significant differences between HypoRT regimens (p > 0·05. The 39 Gy/13 fraction regimen showed the lowest lung NTCP (p < 0·05). HypoRT regimens had significantly lower NTCP for the lungs and heart compared to the conventional regimen (p < 0·01). TCP and NTCP values from Poisson and LKB models were higher than those from the EUD model (p < 0·01).Conclusion:HypoRT regimens reduced NTCP, with the lowest values in the regime of 39 Gy/13 fractions regimen, though the conventional regimen had higher TCP.
ISSN:1460-3969
1467-1131
DOI:10.1017/S1460396924000207