Fabrication and Characterization of Novel Nanocomposite Containing Zn-MOF/Gentamicin/Oxidized Chitosan as a Highly Effective Antimicrobial Agent

• Published in: Journal of inorganic and organometallic polymers and materials 2024, Vol.34 (9), p.4321-4331
• Main Authors: Ali, Eyhab, Al-Saedi, Haider Falih Shamikh, Hussein, Shaymaa Abed, Mustafa, Nadia Khalid, abdulridui, Hussam abdali, Al-Abdeen, Salah Hassan Zain, Muzammil, Khursheed, Ramadan, Montather F., Hizam, Manar Mohammed, Alawadi, Ahmed, Alsalamy, Ali
• Format: Article
• Language: English
• Subjects: Antimicrobial agents; Biological activity; Biological effects; Biological properties; Chemistry; Chemistry and Materials Science; Chitosan; Gentamicin; Inorganic Chemistry; Metal-organic frameworks; Nanocomposites; Organic Chemistry; Polymer Sciences; Synthesis; X ray photoelectron spectroscopy; Zinc
• ISSN: 1574-1443; 1574-1451
• DOI: 10.1007/s10904-024-03078-4

Gentamicin is a well-known that is drug effective against a wide range of microbes. It is not effective on some bacterial strains. The combination of gentamicin and other bioactive nanostructures can increase the biological properties of the nanocomposite while maintaining its biological properties. Microwave irradiation was utilized to synthesize novel nanocomposites in this study, which consisted of Zn-MOF, gentamicin, and oxidized chitosan. Its structure using EA, XRD, FT-IR, XPS, EDAX, BET, SEM, and TEM were characterized and confirmed. Antimicrobial evaluations were conducted on various bacterial strains according to the Clinical Laboratory Standards Institute’s standards and guidelines, and IZD, MIC, and MBC were reported. The antimicrobial studies resulted in interesting findings. In general, in antimicrobial activity, MIC of synthesized Zn-MOF/gentamicin/oxidized chitosan nanocomposites between 2 and 128 µg/mL, MBC of 4–256 µg/mL and IZD of 15.5–22.7 mm were observed. It was observed that synthesized Zn-MOF/gentamicin/oxidized chitosan nanocomposites were more effective on the strains where gentamicin was effective, and it is also effective on the strains where gentamicin was not effective. These results can be attributed to the loading of gentamicin on the nano substrate as well as the presence of natural bioactive polymer (oxidized chitosan) and the bioactive metal (zinc) in the structure of the final synthesized nanocomposite as well as high specific surface area, and being nano-sized.