Furoate Based Functionalised Ionic Liquid: Antimicrobial and Antioxidant Studies

• Published in: Critical studies in media communication 2021-01, Vol.74 (3), p.186
• Main Authors: Rama, R, Meenakshi, S, Manjunathan, J, Abirami, G, Karthikeyan, S
• Format: Article
• Language: English
• Subjects: Antiinfectives and antibacterials; Antimicrobial agents; Antioxidants; Bacteria; Chelation; Chemical synthesis; Coliforms; E coli; Ferrous ions; Free radicals; Fungicides; Gram-negative bacteria; Gram-positive bacteria; Hydrogen peroxide; Ionic liquids; NMR; Nuclear magnetic resonance; Scavenging; Spectrophotometry; Sulfonic acid
• ISSN: 1529-5036
• DOI: 10.1071/CH20178

A tetraalkyl ammonium cation and furoate anion based functionalised ionic liquid (FIL), N-methyl-N,N,N-trioctylammonium furoate ([MTOA]+[FA]–) has been synthesised and characterised using FT-IR, NMR, and UV spectroscopic techniques. The in vitro antimicrobial activity of the synthesised FIL against two types of Gram-positive bacteria, namely Staphylococcus aureus and Enterobacter faecalis as well as Gram-negative bacteria, namely Escherichia coli and Pseudomonas aeruginosa was tested using a well diffusion method. Similarly, an antifungal test was done against Candida albicans. [MTOA]+[FA]– showed significant inhibitory effect against all the organisms tested as compared with the chosen standards. Antibacterial activity against gram-positive bacteria (zone of inhibition: 16 to 30 mm) was found to be higher than that of Gram-negative bacteria (zone of inhibition: 11 to 19 mm). Moreover, the antioxidant activity of the synthesised FIL from a ferrous ion (Fe2+) chelating assay and its scavenging activity against 1,1-diphenyl-2-picrylhydrazyl, H2O2, and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) free radical using spectrophotometric methods are reported. The FIL, [MTOA]+[FA]– showed a moderate antioxidant activity.