Role of the Serotonergic System in Functional Recovery after Spinal Cord Injury

The serotonergic system plays an essential role in the modulation of the spinal network activity involved in the control of motor, sensory, and visceral functions. Spinal cord injury (SCI) can induce a state of overexcitation that contributes to pain, spasticity, and autonomic dysfunction. At the sa...

Full description

Saved in:
Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2024-09, Vol.60 (5), p.1943-1959
Main Authors: Konovalova, S. P., Sysoev, Yu. I., Vetlugina, A., Arsentiev, K. A., Musienko, P. E.
Format: Article
Language:English
Subjects:
Animal Physiology
Autonomic nervous system
Axons
Biochemistry
Biomedical and Life Sciences
Evolutionary Biology
Immunosuppressive agents
Life Sciences
Motor task performance
Neurology
Recovery of function
Rehabilitation
Reviews
Serotonin
Spasticity
Spinal cord injuries
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The serotonergic system plays an essential role in the modulation of the spinal network activity involved in the control of motor, sensory, and visceral functions. Spinal cord injury (SCI) can induce a state of overexcitation that contributes to pain, spasticity, and autonomic dysfunction. At the same time, serotonergic axons are known to adapt to pathophysiological changes faster than the other axons and retain the ability to sprout and regenerate after injury. A number of experimental animal studies, as well as some clinical observations, suggest that the serotonergic system is a key endogenous resource for posttraumatic recovery after SCI. Specific therapy may include the administration of serotonergic drugs and intraspinal transplantation of serotonergic neurons. This review addresses the role of the serotonergic system in functional recovery after SCI and the prospects for the use of serotonergic drugs in neurorehabilitation.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093024050235