Abstract 025: Early Pre‐Interventional Neutrophil to lymphocyte Ratio predicts Complete Reperfusion Without Functional Independence After Endovascular Therapy in Patients With Acute Ischemic Stroke: A Multiple‐Center Study

• Published in: Stroke: vascular and interventional neurology 2024-11, Vol.4 (S1)
• Main Authors: Chen, Y, Feng, M, Wong, Z, W Wu, M Galecio‐Castillo, J Ma, Lai, Y, Zhou, S, Regenhardt, R W, Dmytriw, A A, Nguyen, T N, Yan, Z, Yang, S, Chen, X, Zou, W, Z Xu
• Format: Article
• Language: English
• Subjects: Ischemia; Neutrophils; Regression analysis; Stroke
• ISSN: 2694-5746; 2694-5746
• DOI: 10.1161/SVIN.04.suppl_1.025

ObjectiveNeutrophil to lymphocyte ratio (NLR) is an important inflammatory indicator. Our study sought to investigate the correlation between admission NLR and functional recovery after successful reperfusion with endovascular therapy (EVT) in patients with acute ischemic stroke (AIS).MethodsWe performed a retrospective analysis of 245 AIS patients who underwent EVT with complete reperfusion from 4 academic comprehensive stroke centers in China. The primary outcome was functional status 3 months after EVT as measured by the modified Rankin Scale score (mRS). Regression analysis was used to test the association between NRL and futile complete reperfusion without Functional Independence defined as mRS 3‐6.ResultsAmong the 245 enrolled patients, 140 (57.14%) achieved mRS of 0‐2 at 3 months, whereas the remaining 105 patients (42.86%) achieved mRS of 3‐6. Multivariable regression analysis demonstrated that higher NLR was associated with an increased probability of futile reperfusion. Age, diabetes mellitus, baseline National Institute of Health Stroke Scale, Alberta Stroke Program Early CT Score, and parenchymal hematoma type 2, were also independently associated with futile complete reperfusion.ConclusionEarly Pre‐Interventional NLR may be a promising predictor of futile complete reperfusion of patients with AIS undergoing EVT.