Diagnostic and prognostic value of plasma lipocalin-2 levels in patients with metabolic dysfunction–associated steatotic liver disease

BackgroundNon-Alcoholic Fatty Liver Disease, recently better recognised as Metabolic Dysfunction–Associated Steatotic Liver Disease, is the most prevalent form of chronic liver disease at present time. It is estimated to impact 32% of the world's population, hence representing a significant hea...

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Published in:Egyptian Liver Journal 2024-11, Vol.14 (1), p.80-13
Main Authors: ElGhandour, Ahmed Mohamed, Teama, Nahla Mohamed, Kamal, Marwa Abdullah, Nashaat, Ehab Hassan, Ghani, Amani Mohamed Abdel, Abdo, Ahmad Abbas
Format: Article
Language:English
Subjects:
Abdomen
Alcohol
Biomarkers
Body mass index
Diabetes
Diagnostic
Hepatology
Internal medicine
Liver diseases
Males
MASLD
Metabolic Dysfunction–Associated Steatotic Liver Disease
Metabolism
Non-Alcoholic Fatty Liver Disease
Plasma
Plasma Lipocalin-2 Levels
Prognostic
Software
Ultrasonic imaging
Variance analysis
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Summary:BackgroundNon-Alcoholic Fatty Liver Disease, recently better recognised as Metabolic Dysfunction–Associated Steatotic Liver Disease, is the most prevalent form of chronic liver disease at present time. It is estimated to impact 32% of the world's population, hence representing a significant health burden.Aim of the workTo assess the significance of plasma Lipocalin-2 (LCN2) levels in the diagnosis and prognosis of NAFLD patients.Patients and methodsIn this retrospective case–control study we recruited 102 subjects aged between 18 and 70 years. The included participants were split into two study groups. Group I: 51 NAFLD patients (61% men, 39% females) and Group II: 51 healthy controls (51% men and 49% females), for whom plasma LCN2 levels were assessed and correlated with NAFLD fibrosis score, FIB4 and fatty liver index.ResultsIn this study, LCN2 levels in NAFLD patients were significantly greater compared to individuals in the control group (p 
ISSN:2090-6218
2090-6226
DOI:10.1186/s43066-024-00387-8