Optimal vaccination strategies in the control of an infectious disease: a SEIRV model for administration of two vaccines

In this paper, we study the optimal control for an SEIR model adapted to the vaccination strategy of susceptible individuals. There are factors associated with a vaccination campaign that make this strategy not only a public health issue but also an economic one. In this case, optimal control is imp...

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Bibliographic Details
Published in:arXiv.org 2024-11
Main Authors: Santos Junior, Nelson L, Gondim, João A M
Format: Article
Language:English
Subjects:
Disease control
Effectiveness
Infectious diseases
Optimal control
Parameter sensitivity
Public health
Sensitivity analysis
Vaccines
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Summary:In this paper, we study the optimal control for an SEIR model adapted to the vaccination strategy of susceptible individuals. There are factors associated with a vaccination campaign that make this strategy not only a public health issue but also an economic one. In this case, optimal control is important as it minimizes implementation costs. We consider the availability of two vaccines with different efficacy levels, and the control indicates when each vaccine should be used. The optimal strategy specifies in all cases how vaccine purchases should be distributed. For similar efficacy values, we perform a sensitivity analysis on parameters that depend on the intrinsic characteristics of the vaccines. Additionally, we investigate the behavior of the number of infections under the optimal vaccination strategy.
ISSN:2331-8422