Analysis of G:C>T:A, G:C>A:T, and G:C>C:G Mutations in the TP53 Gene in Women with and without Breast Cancer in the Long-Term Period after Chronic Radiation Exposure

The results of analysis of mutations such as G:C>T:A, G:C>A:T, and G:C>C:G in the TP53 gene in peripheral blood cells in women affected by chronic radiation exposure with breast cancer (24 women) and without breast cancer (17 women) are presented. Seventeen different variants representing s...

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Bibliographic Details
Published in:Biology bulletin of the Russian Academy of Sciences 2024, Vol.51 (6), p.1597-1604
Main Authors: Nikiforov, V. S., Korechenkova, A. V., Akleyev, A. V.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Blood cells
Breast cancer
Cell Biology
Ecology
Genetics
Life Sciences
Mutation
p53 Protein
Peripheral blood
Statistical analysis
Zoology
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Summary:The results of analysis of mutations such as G:C>T:A, G:C>A:T, and G:C>C:G in the TP53 gene in peripheral blood cells in women affected by chronic radiation exposure with breast cancer (24 women) and without breast cancer (17 women) are presented. Seventeen different variants representing single nucleotide substitutions were registered. The differences in the frequencies of carriers of the detected variants between the comparison and the main group were not statistically significant. All detected variants were present in the IARC TP53 database and had no clinical significance as “pathogenic.” Despite the absence of statistically significant differences, the question of the effect of chronic low dose rate exposure on the frequency of mutations in the TP53 gene remains open and requires further research involving a greater quantity of data.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359024610267