A reduced graphene oxide-coated conductive surgical silk suture targeting microresistance sensing changes for wound healing

Conventional sutures used in surgical procedures often lack the capability to effectively monitor physical and chemical activities or the microbial environment of surgical wounds due to their inadequate mechanical properties, insufficient electrical accuracy and unstability. Here, we present a strai...

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Bibliographic Details
Published in:Science China. Technological sciences 2024-11, Vol.67 (11), p.3499-3512
Main Authors: Ding, YuQi, Wang, XuChen, Liu, JingGe, Shen, HongQiang, Wang, Zhong, Xie, MaoBin, Chen, Ying, Barcenas, Adileidys Ruiz, Zhao, ZeYu, Li, Gang
Format: Article
Language:English
Subjects:
Ascorbic acid
Bonding strength
Electrical resistivity
Engineering
Graphene
Hydrogen bonds
Mechanical properties
Microorganisms
Raman spectroscopy
Silk
Silk fibroin
Sutures
Tensile strength
Wound healing
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Summary:Conventional sutures used in surgical procedures often lack the capability to effectively monitor physical and chemical activities or the microbial environment of surgical wounds due to their inadequate mechanical properties, insufficient electrical accuracy and unstability. Here, we present a straightforward layer-by-layer coating technique that utilizes 3-glycidoxypropyltrimethoxysilane (CA), graphene oxide (GO), and ascorbic acid (AA) to develop conductive silk-based surgical sutures (CA-rGSFS). The CA-rGSFS feature a continuous reduced graphene oxide (rGO) film on their surface, forming robust hydrogen bonds with silk fibroin. The reduction process of rGO is confirmed through Raman analysis, demonstrating an enhanced D peak to G peak ratio. Notably, the CA-rGSFS exhibit exceptional mechanical properties and efficient electron transmission, with a knot-pull tensile strength of 2089.72 ± 1.20 cN and an electrical conductivity of 130.30 ± 11.34 S/m, respectively, meeting the requirements specified by the United States Pharmacopeia (USP) for 2-0 sutures. These novel CA-rGSFS demonstrate the ability to accurately track resistance changes in various fluid environments with rapid response, including saline, intestinal, and gastric fluids. The suture also retains remarkable stretchablility and stability even after enduring 3000 tensile cycles, highlighting their potential for precise surgical site monitoring during the wound healing process.
ISSN:1674-7321
1869-1900
DOI:10.1007/s11431-024-2710-5