Genomic strategies for drug repurposing

Functional genomics, a multidisciplinary subject, investigates the functions of genes and their products in biological systems to better understand diseases and find new drugs. Drug repurposing is an economically efficient approach that entails discovering novel therapeutic applications for already-...

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Bibliographic Details
Published in:Journal of Egyptian National Cancer Institute 2024-11, Vol.36 (1), p.35-12
Main Authors: Dave, Kirtan, Patel, Dhaval, Dave, Nischal, Jain, Mukul
Format: Article
Language:English
Subjects:
Artificial intelligence
Cancer
Cancer therapies
Cell cycle
Computer science
CRISPR
Data mining
Disease
Drug development
Drug discovery
Drug repurposing
Drugs
Gene expression
Genes
Genetics
Genomes
Genomics
Health aspects
Homeopathy
Kinases
Materia medica and therapeutics
NGS
Ontology
Open source software
Pharmacogenetics
Phosphorylation
Proteins
Proteomics
R&D
Research & development
Therapeutics
Visualization
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Summary:Functional genomics, a multidisciplinary subject, investigates the functions of genes and their products in biological systems to better understand diseases and find new drugs. Drug repurposing is an economically efficient approach that entails discovering novel therapeutic applications for already-available medications. Genomics enables the identification of illness and therapeutic molecular characteristics and interactions, which in turn facilitates the process of drug repurposing. Techniques like gene expression profiling and Mendelian randomization are helpful in identifying possible medication candidates. Progress in computer science allows for the investigation and modeling of gene expression networks that involve large amounts of data. The amalgamation of data concerning DNA, RNA, and protein functions bears similarity to pharmacogenomics, a crucial aspect in crafting cancer therapeutics. Functional genomics in drug discovery, particularly for cancer, is still not thoroughly investigated, despite the existence of a significant amount of literature on the subject. Next-generation sequencing and proteomics present highly intriguing opportunities. Publicly available databases and mining techniques facilitate the development of cancer treatments based on functional genomics. Broadening the exploration and utilization of functional genomics holds significant potential for advancing drug discovery and repurposing, particularly within the realm of oncology.
ISSN:1110-0362
2589-0409
DOI:10.1186/s43046-024-00245-z