Loading…

Accelerating Diverse Cell-Based Therapies Through Scalable Design

Augmenting cells with novel, genetically encoded functions will support therapies that expand beyond natural capacity for immune surveillance and tissue regeneration. However, engineering cells at scale with transgenic cargoes remains a challenge in realizing the potential of cell-based therapies. I...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of chemical and biomolecular engineering 2024-01, Vol.15 (1), p.267-292
Main Authors: Peterman, Emma L, Ploessl, Deon S, Galloway, Kate E
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-a288t-73669d97b0d5f9435910c56cab16a3aa2e0514fcdd04429a72739e3690ffc6803
container_end_page 292
container_issue 1
container_start_page 267
container_title Annual review of chemical and biomolecular engineering
container_volume 15
creator Peterman, Emma L
Ploessl, Deon S
Galloway, Kate E
description Augmenting cells with novel, genetically encoded functions will support therapies that expand beyond natural capacity for immune surveillance and tissue regeneration. However, engineering cells at scale with transgenic cargoes remains a challenge in realizing the potential of cell-based therapies. In this review, we introduce a range of applications for engineering primary cells and stem cells for cell-based therapies. We highlight tools and advances that have launched mammalian cell engineering from bioproduction to precision editing of therapeutically relevant cells. Additionally, we examine how transgenesis methods and genetic cargo designs can be tailored for performance. Altogether, we offer a vision for accelerating the translation of innovative cell-based therapies by harnessing diverse cell types, integrating the expanding array of synthetic biology tools, and building cellular tools through advanced genome writing techniques.
doi_str_mv 10.1146/annurev-chembioeng-100722-121610
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_3128361973</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3128361973</sourcerecordid><originalsourceid>FETCH-LOGICAL-a288t-73669d97b0d5f9435910c56cab16a3aa2e0514fcdd04429a72739e3690ffc6803</originalsourceid><addsrcrecordid>eNqVkF1LwzAUQIMobk7_ghR82Us1adKkeXNu8wMGPjifQ5redh39mMk68d-b0TnBN59yIYdzLwehMcG3hDB-p5ums7ALzQrqtGyhKUKCsYiikESEE3yChkQyEcaM8dPjTJMBunBujTEXCWfnaECTWDLJ2BBNJsZABVZvy6YIZuUOrINgClUVPmgHWbBc-c9NCc5Ptu2KVfBmdKXTCoIZuLJoLtFZrisHV4d3hN4f58vpc7h4fXqZThahjpJkGwrKucykSHEW55LRWBJsYm50SrimWkeAY8Jyk2WYsUhqEQkqgXKJ89zwBNMRGvfejW0_OnBbVZfO317pBtrOKYppHDMiSOLRmz_ouu1s469TlEQJ5UQK6qn7njK2dc5Crja2rLX9UgSrfW51yK1-c6s-t-pze8X1YVGX1pAdBT99PTDvgb1KV15Wwqf7_6JvKKuYAQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3128361973</pqid></control><display><type>article</type><title>Accelerating Diverse Cell-Based Therapies Through Scalable Design</title><source>Annual Reviews Open Access</source><creator>Peterman, Emma L ; Ploessl, Deon S ; Galloway, Kate E</creator><creatorcontrib>Peterman, Emma L ; Ploessl, Deon S ; Galloway, Kate E</creatorcontrib><description>Augmenting cells with novel, genetically encoded functions will support therapies that expand beyond natural capacity for immune surveillance and tissue regeneration. However, engineering cells at scale with transgenic cargoes remains a challenge in realizing the potential of cell-based therapies. In this review, we introduce a range of applications for engineering primary cells and stem cells for cell-based therapies. We highlight tools and advances that have launched mammalian cell engineering from bioproduction to precision editing of therapeutically relevant cells. Additionally, we examine how transgenesis methods and genetic cargo designs can be tailored for performance. Altogether, we offer a vision for accelerating the translation of innovative cell-based therapies by harnessing diverse cell types, integrating the expanding array of synthetic biology tools, and building cellular tools through advanced genome writing techniques.</description><identifier>ISSN: 1947-5438</identifier><identifier>ISSN: 1947-5446</identifier><identifier>EISSN: 1947-5446</identifier><identifier>DOI: 10.1146/annurev-chembioeng-100722-121610</identifier><identifier>PMID: 38594944</identifier><language>eng</language><publisher>United States: Annual Reviews</publisher><subject>biomanufacturing ; Cargo capacity ; cell-based therapies ; cellular engineering ; Genetic code ; genome editing ; Immune system ; Immunosurveillance ; Regeneration (physiology) ; Stem cells ; synthetic biology ; Tissue engineering</subject><ispartof>Annual review of chemical and biomolecular engineering, 2024-01, Vol.15 (1), p.267-292</ispartof><rights>Copyright Annual Reviews, Inc. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a288t-73669d97b0d5f9435910c56cab16a3aa2e0514fcdd04429a72739e3690ffc6803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-chembioeng-100722-121610?crawler=true&amp;mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-chembioeng-100722-121610$$EHTML$$P50$$Gannualreviews$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,27892,27924,27925,78360,78465</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38594944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peterman, Emma L</creatorcontrib><creatorcontrib>Ploessl, Deon S</creatorcontrib><creatorcontrib>Galloway, Kate E</creatorcontrib><title>Accelerating Diverse Cell-Based Therapies Through Scalable Design</title><title>Annual review of chemical and biomolecular engineering</title><addtitle>Annu Rev Chem Biomol Eng</addtitle><description>Augmenting cells with novel, genetically encoded functions will support therapies that expand beyond natural capacity for immune surveillance and tissue regeneration. However, engineering cells at scale with transgenic cargoes remains a challenge in realizing the potential of cell-based therapies. In this review, we introduce a range of applications for engineering primary cells and stem cells for cell-based therapies. We highlight tools and advances that have launched mammalian cell engineering from bioproduction to precision editing of therapeutically relevant cells. Additionally, we examine how transgenesis methods and genetic cargo designs can be tailored for performance. Altogether, we offer a vision for accelerating the translation of innovative cell-based therapies by harnessing diverse cell types, integrating the expanding array of synthetic biology tools, and building cellular tools through advanced genome writing techniques.</description><subject>biomanufacturing</subject><subject>Cargo capacity</subject><subject>cell-based therapies</subject><subject>cellular engineering</subject><subject>Genetic code</subject><subject>genome editing</subject><subject>Immune system</subject><subject>Immunosurveillance</subject><subject>Regeneration (physiology)</subject><subject>Stem cells</subject><subject>synthetic biology</subject><subject>Tissue engineering</subject><issn>1947-5438</issn><issn>1947-5446</issn><issn>1947-5446</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ZYWBE</sourceid><recordid>eNqVkF1LwzAUQIMobk7_ghR82Us1adKkeXNu8wMGPjifQ5redh39mMk68d-b0TnBN59yIYdzLwehMcG3hDB-p5ums7ALzQrqtGyhKUKCsYiikESEE3yChkQyEcaM8dPjTJMBunBujTEXCWfnaECTWDLJ2BBNJsZABVZvy6YIZuUOrINgClUVPmgHWbBc-c9NCc5Ptu2KVfBmdKXTCoIZuLJoLtFZrisHV4d3hN4f58vpc7h4fXqZThahjpJkGwrKucykSHEW55LRWBJsYm50SrimWkeAY8Jyk2WYsUhqEQkqgXKJ89zwBNMRGvfejW0_OnBbVZfO317pBtrOKYppHDMiSOLRmz_ouu1s469TlEQJ5UQK6qn7njK2dc5Crja2rLX9UgSrfW51yK1-c6s-t-pze8X1YVGX1pAdBT99PTDvgb1KV15Wwqf7_6JvKKuYAQ</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Peterman, Emma L</creator><creator>Ploessl, Deon S</creator><creator>Galloway, Kate E</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>ZYWBE</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20240101</creationdate><title>Accelerating Diverse Cell-Based Therapies Through Scalable Design</title><author>Peterman, Emma L ; Ploessl, Deon S ; Galloway, Kate E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a288t-73669d97b0d5f9435910c56cab16a3aa2e0514fcdd04429a72739e3690ffc6803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>biomanufacturing</topic><topic>Cargo capacity</topic><topic>cell-based therapies</topic><topic>cellular engineering</topic><topic>Genetic code</topic><topic>genome editing</topic><topic>Immune system</topic><topic>Immunosurveillance</topic><topic>Regeneration (physiology)</topic><topic>Stem cells</topic><topic>synthetic biology</topic><topic>Tissue engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peterman, Emma L</creatorcontrib><creatorcontrib>Ploessl, Deon S</creatorcontrib><creatorcontrib>Galloway, Kate E</creatorcontrib><collection>Annual Reviews Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts – Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of chemical and biomolecular engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peterman, Emma L</au><au>Ploessl, Deon S</au><au>Galloway, Kate E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accelerating Diverse Cell-Based Therapies Through Scalable Design</atitle><jtitle>Annual review of chemical and biomolecular engineering</jtitle><addtitle>Annu Rev Chem Biomol Eng</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>15</volume><issue>1</issue><spage>267</spage><epage>292</epage><pages>267-292</pages><issn>1947-5438</issn><issn>1947-5446</issn><eissn>1947-5446</eissn><abstract>Augmenting cells with novel, genetically encoded functions will support therapies that expand beyond natural capacity for immune surveillance and tissue regeneration. However, engineering cells at scale with transgenic cargoes remains a challenge in realizing the potential of cell-based therapies. In this review, we introduce a range of applications for engineering primary cells and stem cells for cell-based therapies. We highlight tools and advances that have launched mammalian cell engineering from bioproduction to precision editing of therapeutically relevant cells. Additionally, we examine how transgenesis methods and genetic cargo designs can be tailored for performance. Altogether, we offer a vision for accelerating the translation of innovative cell-based therapies by harnessing diverse cell types, integrating the expanding array of synthetic biology tools, and building cellular tools through advanced genome writing techniques.</abstract><cop>United States</cop><pub>Annual Reviews</pub><pmid>38594944</pmid><doi>10.1146/annurev-chembioeng-100722-121610</doi><tpages>26</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1947-5438
ispartof Annual review of chemical and biomolecular engineering, 2024-01, Vol.15 (1), p.267-292
issn 1947-5438
1947-5446
1947-5446
language eng
recordid cdi_proquest_journals_3128361973
source Annual Reviews Open Access
subjects biomanufacturing
Cargo capacity
cell-based therapies
cellular engineering
Genetic code
genome editing
Immune system
Immunosurveillance
Regeneration (physiology)
Stem cells
synthetic biology
Tissue engineering
title Accelerating Diverse Cell-Based Therapies Through Scalable Design
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T06%3A23%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Accelerating%20Diverse%20Cell-Based%20Therapies%20Through%20Scalable%20Design&rft.jtitle=Annual%20review%20of%20chemical%20and%20biomolecular%20engineering&rft.au=Peterman,%20Emma%20L&rft.date=2024-01-01&rft.volume=15&rft.issue=1&rft.spage=267&rft.epage=292&rft.pages=267-292&rft.issn=1947-5438&rft.eissn=1947-5446&rft_id=info:doi/10.1146/annurev-chembioeng-100722-121610&rft_dat=%3Cproquest_cross%3E3128361973%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a288t-73669d97b0d5f9435910c56cab16a3aa2e0514fcdd04429a72739e3690ffc6803%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3128361973&rft_id=info:pmid/38594944&rfr_iscdi=true