The Search for Safer Glucocorticoid Receptor Ligands

Steroidal glucocorticoids are commonly used due to their powerful antiinflammatory activity. However, despite their excellent efficacy, severe side effects frequently limit the use of these drugs. The search for novel glucocorticoids with reduced side effects has been intensified by the discovery of...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine reviews 2005-05, Vol.26 (3), p.452-464
Main Authors: Rosen, Jonathan, Miner, Jeffrey N
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents - adverse effects
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Benzopyrans - adverse effects
Benzopyrans - pharmacology
Benzopyrans - therapeutic use
Drug discovery
Effectiveness
Glucocorticoid receptors
Glucocorticoids
Glucocorticoids - adverse effects
Glucocorticoids - pharmacology
Glucocorticoids - therapeutic use
Humans
Inflammation - drug therapy
Ligands
Quinolines - adverse effects
Quinolines - pharmacology
Quinolines - therapeutic use
Receptors
Receptors, Glucocorticoid - metabolism
Side effects
Steroid hormones
Steroids
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Steroidal glucocorticoids are commonly used due to their powerful antiinflammatory activity. However, despite their excellent efficacy, severe side effects frequently limit the use of these drugs. The search for novel glucocorticoids with reduced side effects has been intensified by the discovery of new molecular details regarding the function of the glucocorticoid receptor. These new insights may pave the way for novel, safer therapies that retain the efficacy of currently prescribed steroids.
ISSN:0163-769X
1945-7189
DOI:10.1210/er.2005-0002