Expression, Exon-Intron Organization, and Chromosome Mapping of the Human Sodium Iodide Symporter

The active iodide uptake of the thyroid gland in humans is mediated by the human sodium iodide symporter (hNIS). In this report, we show that hNIS expression was detected primarily in thyroid tissue, but also in breast, colon, and ovary tissues. Expression of hNIS is greatly reduced in thyroid tumor...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 1997-08, Vol.138 (8), p.3555-3558
Main Authors: Smanik, Patricia A, Ryu, Kwon-Yul, Theil, Karl S, Mazzaferri, Ernest L, Jhiang, Sissy M
Format: Article
Language:English
Subjects:
Alternative splicing
Chromosome 19
Chromosomes
Gene mapping
Introns
Iodides
Nucleotide sequence
Nucleotides
Sodium
Sodium iodide
Sodium iodide symporter
Thyroid
Thyroid carcinoma
Thyroid gland
Tumors
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Summary:The active iodide uptake of the thyroid gland in humans is mediated by the human sodium iodide symporter (hNIS). In this report, we show that hNIS expression was detected primarily in thyroid tissue, but also in breast, colon, and ovary tissues. Expression of hNIS is greatly reduced in thyroid tumors compared to normal thyroid tissue. Among tumor tissues, hNIS expression appears to be variable, consistent with the variable response to radioiodide treatment observed for thyroid carcinomas. The coding region of hNIS is interrupted by 14 introns, and the nucleotide sequence of each exon-intron junction is reported. Using this information, an alternatively spliced form of hNIS was identified. Finally, the chromosome location of the hNIS gene was mapped to chromosome 19p.
ISSN:0013-7227
1945-7170
DOI:10.1210/endo.138.8.5262