Aldosterone: A Mediator of Myocardial Necrosis and Renal Arteriopathy

Abstract To determine the role of aldosterone in mediating cardiovascular damage, we performed ablation/replacement experiments with aldosterone in a rat model of cardiac injury. Administration of angiotensin II and Nω-nitro-l-arginine methyl ester (L-NAME; nitric oxide synthesis inhibitor) to male...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 2000-10, Vol.141 (10), p.3871-3878
Main Authors: Rocha, Ricardo, Stier, Charles T., Kifor, Imre, Ochoa-Maya, Margarita R., Rennke, Helmut G., Williams, Gordon H., Adler, Gail K.
Format: Article
Language:English
Subjects:
Ablation
Adrenalectomy
Aldosterone
Aldosterone - blood
Aldosterone - physiology
Angiotensin
Angiotensin II
Angiotensin II - pharmacology
Animals
Arginine
Blood pressure
Blood Pressure - drug effects
Cardiomyopathies - chemically induced
Cardiomyopathies - pathology
Damage detection
Enzyme Inhibitors - pharmacology
Glucocorticoids
Heart
Hormone Antagonists - pharmacology
Hypertension
Kidney - pathology
Male
Myocardium - pathology
Necrosis
NG-Nitroarginine methyl ester
NG-Nitroarginine Methyl Ester - pharmacology
Nitric oxide
Pressure effects
Proteinuria
Rats
Rats, Wistar
Renal Artery
Renin - blood
Sodium Chloride
Spironolactone - analogs & derivatives
Spironolactone - pharmacology
Vascular Diseases - physiopathology
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Summary:Abstract To determine the role of aldosterone in mediating cardiovascular damage, we performed ablation/replacement experiments with aldosterone in a rat model of cardiac injury. Administration of angiotensin II and Nω-nitro-l-arginine methyl ester (L-NAME; nitric oxide synthesis inhibitor) to male rats drinking 1% saline caused hypertension, severe biventricular myocardial necrosis, proteinuria, and fibrinoid necrosis of renal and cardiac vessels. Removal of aldosterone by adrenalectomy or through administration of the selective aldosterone antagonist eplerenone markedly reduced the cardiac and renal damage without significantly altering blood pressure. Aldosterone infusion in adrenalectomized, glucocorticoid-replaced L-NAME/angiotensin II-treated animals restored damage. Thus, we identified aldosterone as a critical mediator of L-NAME/angiotensine II induced vascular damage through mechanisms apparently independent of its effects on systolic blood pressure.
ISSN:0013-7227
1945-7170
DOI:10.1210/endo.141.10.7711