Is the Early Increase in Leptinemia One of the Anorectic Signals Induced by an Essential Amino Acid-Deficient Diet in the Rat?

Rats start decreasing their food intake as early as 70 min after the first ingestion of a food deficient in threonine. A decrease of the limiting essential amino acid (EAA) in the plasma was proposed to be the first anorectic signal. Because many hormones regulate feeding behavior, we studied the ef...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 2000-10, Vol.141 (10), p.3916-3919
Main Authors: Feurté, Sebastien, Nicolaïdis, Stylianos, Gerozissis, Kyriaki
Format: Article
Language:English
Subjects:
Amino acids
Diet
Feeding behavior
Food intake
Glucagon
Hormones
Ingestion
Insulin
Leptin
Nutrient deficiency
Radioimmunoassay
Threonine
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Summary:Rats start decreasing their food intake as early as 70 min after the first ingestion of a food deficient in threonine. A decrease of the limiting essential amino acid (EAA) in the plasma was proposed to be the first anorectic signal. Because many hormones regulate feeding behavior, we studied the effect of a meal (46 kJ) that was either devoid of threonine or was corrected for the deficiency, on plasma leptin, insulin and glucagon levels using a radio-immunoassay, at 0 to 180 min after the meal. One hour after ingestion of the threonine-devoid meal, a larger increase in insulinemia (22±1 vs. 15±1 μU/ml) and leptinemia (7.8±0.5 vs. 4.4±0.6 ng/ml; p
ISSN:0013-7227
1945-7170
DOI:10.1210/endo.141.10.7800