Glucagon-Like Peptide-1 Regulates the Beta Cell Transcription Factor, PDX-1, in Insulinoma Cells

Glucagon-like peptide-1 (GLP-1) enhances insulin biosynthesis and secretion as well as transcription of the insulin, GLUT2 and glucokinase genes. The latter are also regulated by the PDX-1 homeoprotein. We investigated the possibility that GLP-1 may be having its long-term pleiotropic effects throug...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 1999-10, Vol.140 (10), p.4904-4907
Main Authors: Wang, Xiaolin, Cahill, Catherine M, Piñeyro, Marco A, Zhou, Jie, Doyle, Máire E, Egan, Josephine M
Format: Article
Language:English
Subjects:
Beta cells
Biosynthesis
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Electrophoretic mobility
Glucagon
Glucagon-like peptide 1
Glucokinase
Glucose transporter
Insulin
Insulinoma
Pdx-1 protein
Peptides
Protein folding
Proteins
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Summary:Glucagon-like peptide-1 (GLP-1) enhances insulin biosynthesis and secretion as well as transcription of the insulin, GLUT2 and glucokinase genes. The latter are also regulated by the PDX-1 homeoprotein. We investigated the possibility that GLP-1 may be having its long-term pleiotropic effects through a hitherto unknown regulation of PDX-1. We found that PDX-1 mRNA level was significantly increased (p
ISSN:0013-7227
1945-7170
DOI:10.1210/endo.140.10.7158