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Uterine Natural Killer Cells Are Targets for a Trophoblast Cell-Specific Cytokine, Prolactin-Like Protein A

Abstract PRL-like protein A (PLP-A) is a member of the PRL family expressed in trophoblast cells coincident with establishment of the chorioallantoic placenta. The purpose of this investigation was to identify targets for PLP-A. Using an alkaline phosphatase-tagging strategy, we show that PLP-A spec...

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Published in:	Endocrinology (Philadelphia) 1999-06, Vol.140 (6), p.2711-2720
Main Authors:	Müller, Heiner, Liu, Bing, Croy, B. Anne, Head, Judith R., Hunt, Joan S., Dai, Guoli, Soares, Michael J.
Format:	Article
Language:	English
Subjects:	Alkaline phosphatase Cell interactions Cell surface Decidua Lymphocytes Natural killer cells Placenta Prolactin Protein A Proteins Pseudopregnancy Signal transduction Surface markers Uterus
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description	Abstract PRL-like protein A (PLP-A) is a member of the PRL family expressed in trophoblast cells coincident with establishment of the chorioallantoic placenta. The purpose of this investigation was to identify targets for PLP-A. Using an alkaline phosphatase-tagging strategy, we show that PLP-A specifically interacts with a population of natural killer (NK) lymphocytes within the mesometrial compartment of decidua from pregnant and pseudopregnant rats. These observations are supported by the codistribution of PLP-A targets with cells expressing the rat NK cell surface marker, gp42, the absence of PLP-A binding in conceptuses from NK cell-deficient tgε26 mice, and the specific interaction of PLP-A with a rat NK cell line, RNK-16. We have further demonstrated that PLP-A effectively suppresses RNK-16 cell cytolytic activities. Our results provide evidence for a new paradigm of embryonic-maternal communication involving a PLP-A signaling pathway between trophoblast cells and uterine NK lymphocytes.
doi_str_mv	10.1210/endo.140.6.6828
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These observations are supported by the codistribution of PLP-A targets with cells expressing the rat NK cell surface marker, gp42, the absence of PLP-A binding in conceptuses from NK cell-deficient tgε26 mice, and the specific interaction of PLP-A with a rat NK cell line, RNK-16. We have further demonstrated that PLP-A effectively suppresses RNK-16 cell cytolytic activities. Our results provide evidence for a new paradigm of embryonic-maternal communication involving a PLP-A signaling pathway between trophoblast cells and uterine NK lymphocytes.</description><subject>Alkaline phosphatase</subject><subject>Cell interactions</subject><subject>Cell surface</subject><subject>Decidua</subject><subject>Lymphocytes</subject><subject>Natural killer cells</subject><subject>Placenta</subject><subject>Prolactin</subject><subject>Protein A</subject><subject>Proteins</subject><subject>Pseudopregnancy</subject><subject>Signal transduction</subject><subject>Surface markers</subject><subject>Uterus</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkM1LwzAYxoMoOKdnrwFvYrt8temOo_iFQwXrOaRpotliU5P0sP_eznn39PLA73le-AFwiVGOCUYL3Xc-xwzlZV5WpDoCM7xkRcYxR8dghhCmGSeEn4KzGDdTZIzRGdi-Jx1sr-GzTGOQDj5Z53SAtXYuwlXQsJHhQ6cIjQ9Qwib44dO3Tsb0y2Rvg1bWWAXrXfLbaekGvgbvpEq2z9Z2q_cxadvD1Tk4MdJFffF356C5u23qh2z9cv9Yr9aZooRVWVmxkqKOFxVb6pZ1JWMKtwXlFBmJS6kkMtRwXiheLDElhqKCUNJR07WUIzoHV4fZIfjvUcckNn4M_fRRUDyxuOKETtTiQKngYwzaiCHYLxl2AiOxFyr2QsUkVJRiL3RqXB8afhz-hX8Af8d1qA</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Müller, Heiner</creator><creator>Liu, Bing</creator><creator>Croy, B. 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subjects	Alkaline phosphatase Cell interactions Cell surface Decidua Lymphocytes Natural killer cells Placenta Prolactin Protein A Proteins Pseudopregnancy Signal transduction Surface markers Uterus
title	Uterine Natural Killer Cells Are Targets for a Trophoblast Cell-Specific Cytokine, Prolactin-Like Protein A
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