Fibroblast Growth Factor-9 Is an Endometrial Stromal Growth Factor

Fibroblast growth factor-9 (FGF-9) is an autocrine/paracrine growth factor considered to be important for the growth and survival of motorneurons and prostate. In this study, we found that FGF-9 was expressed at high levels in normal uterine endometrium, especially during the late proliferative phas...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 2002-07, Vol.143 (7), p.2715-2721
Main Authors: Tsai, Shaw-Jenq, Wu, Meng-Hsing, Chen, Hsiu-Mei, Chuang, Pei-Chin, Wing, Lih-Yuh C
Format: Article
Language:English
Subjects:
17β-Estradiol
Autocrine signalling
Cell proliferation
Endometrium
Epithelial cells
Epithelium
Fibroblast growth factor receptor 9
Fibroblast growth factors
Fibroblasts
Growth factors
Motor neurons
mRNA
Paracrine signalling
Progesterone
Sex hormones
Stromal cells
Uterus
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Summary:Fibroblast growth factor-9 (FGF-9) is an autocrine/paracrine growth factor considered to be important for the growth and survival of motorneurons and prostate. In this study, we found that FGF-9 was expressed at high levels in normal uterine endometrium, especially during the late proliferative phase, which is coincident with the rise of estradiol and the time of uterine endometrial proliferation. Using quantitative RT-PCR analysis, we found that FGF-9 mRNA was expressed primarily by endometrial stromal cells. High affinity receptors of FGF-9 were detected in both epithelial and stromal cells but with distinct patterns. FGFR2IIIc and FGFR3IIIc are abundant in endometrial stromal cell. FGFR2IIIb is mostly expressed in endometrial epithelial cells, whereas FGFR3IIIb is found in both epithelial and stromal cells. Treatment with FGF-9 induces endometrial stromal proliferation in a dose-dependent manner. Expression of FGF-9 in stromal cells was induced by 17β-estradiol but not by progesterone. Furthermore, the administration of 17β-estradiol stimulates endometrial stromal cell proliferation and that can be inhibited by cotreatment with anti-FGF-9 antibody. Herein we demonstrate, for the first time, that FGF-9 is an autocrine estromedin endometrial stromal growth factor that plays roles in cyclic proliferation of uterine endometrial stroma.
ISSN:0013-7227
1945-7170
DOI:10.1210/endo.143.7.8900