Multifunctional Citral–Tryptamine Conjugated Silver Nanoparticles (CT@AgNPs): Antibacterial, Cytotoxicity, and Sensor Application

The present study reports the synthesis of multifunctional silver nanoparticles using citral–tryptamine (CT@AgNPs). In this approach, synthesis of citral–tryptamine-based Schiff base (CT) was characterized using various spectral studies such as NMR, FT-IR, and LCMS. The various biological properties...

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Bibliographic Details
Published in:BioNanoScience 2024-12, Vol.14 (5), p.5106-5121
Main Authors: Deviprasad, M. J., Hemanth, B. S., Shivaswamy, M. B., Nagendra Prasad, H. S., Sumathi, Sundaravadivelu, Aswathy, R., Sangamesha, M. A., Ananda, A. P., Jayanth, H. S., Lohith, T. N.
Format: Article
Language:English
Subjects:
Antibacterial activity
Anticancer properties
Antiinfectives and antibacterials
Biocompatibility
Biological and Medical Physics
Biological properties
Biomaterials
Biophysics
Cervical cancer
Chemical synthesis
Circuits and Systems
Citral
Cytotoxicity
Drug resistance
Engineering
Imines
Methicillin
Molecular docking
Nanoparticles
Nanotechnology
NMR
Nuclear magnetic resonance
Silver
Staphylococcus infections
Tryptamine
Tryptamines
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Summary:The present study reports the synthesis of multifunctional silver nanoparticles using citral–tryptamine (CT@AgNPs). In this approach, synthesis of citral–tryptamine-based Schiff base (CT) was characterized using various spectral studies such as NMR, FT-IR, and LCMS. The various biological properties were investigated using ADME, Bioactive, and molecular docking analysis of CT compound. Interaction and binding affinities toward protein IDs 6SJA and 3DAQ were significant. Silver nanoparticles were synthesized by reduction method using CT compound and confirmed by XRD, EDX, SEM, and DLS analysis. Herein, CT@AgNPs have an average diameter of 52 nm. The silver nanoparticle exhibited enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA); the MIC value is 15 ± 0.50 µg/mL. These nanoparticles showed remarkable toxic effect against SiHa cervical cancer cell line, and obtained IC 50 value is 100 µg/mL. Additionally, we propound the rapid, sensitive, and cost-effective electrochemical approach for detection of nitrite with linear dynamic range of 0.4 to 4.0 mM with a lower detection limit of 0.4 mM. These results advocate promising antibacterial and anticancer properties of CT@AgNPs for futuristic therapeutics and sensor application.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-024-01583-x