Comparative Evaluation of Wound Healing Efficacy of Bombyx mori L. Body Extracts, Gland Extracts, and Cocoon for the Treatment of Second-Degree Burns: A Pilot Study

Background: The silkworm (Bombyx mori L.) and its cocoon are rich in bioactive proteins like sericin and fibroin, as well as enzymes such as serrapeptase, which possess anti-inflammatory and skin-healing properties. This study aimed to evaluate the in vivo effects of various silkworm products, inclu...

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Bibliographic Details
Published in:Processes 2024-11, Vol.12 (11), p.2594
Main Authors: Kyriaki, Alexandra, Vidali, Margarita, Vitsos, Andreas, Harizanis, Paschalis, Sfiniadakis, Ioannis, Barda, Christina, Simirioti, Eleftheria, Terezaki, Asimina, Rallis, Michail Christou
Format: Article
Language:English
Subjects:
Bombyx mori
Burns
Burns and scalds
Care and treatment
Cocoons
Effectiveness
Enzymes
Evaluation
Glands
Hairless
Hydration
In vivo methods and tests
Inflammation
Pilot projects
Silkworms
Skin
Statistical analysis
Thickness measurement
Water loss
Wound healing
Wounds and injuries
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Summary:Background: The silkworm (Bombyx mori L.) and its cocoon are rich in bioactive proteins like sericin and fibroin, as well as enzymes such as serrapeptase, which possess anti-inflammatory and skin-healing properties. This study aimed to evaluate the in vivo effects of various silkworm products, including cocoon patches and extracts from the silkworm body and glands, on the healing of second-degree burns. Methods: Hairless, female SKH-2 mice were used to model second-degree burns. The study tested formulations containing 1%, 10%, or 20% silkworm body or gland extracts, as well as cocoon-derived patches. In addition to histopathological and clinical assessments, the study measured parameters including burn size, hydration, transepidermal water loss and thickness. Results: The results of this study demonstrated that, in terms of primary outcomes (complete healing), both the silkworm cocoon and the 20% body extract significantly promoted wound healing, with similar efficacy. All body extracts showed statistical significance in wound area reduction, while the gland extracts had no significant effect. Histopathological evaluation confirmed the superior healing potential of the body extracts increasing by increased concentration and cocoon. This novel insight into the therapeutic properties of silkworm body extracts opens new opportunities for the development of cost-effective, renewable second-degree burn healing treatments.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr12112594