Plasmacytoid urothelial carcinoma – A clinicopathological case series of an aggressive variant of urothelial cancer

Background: Many new morphological variants of urothelial carcinoma of urinary bladder have been described in the literature, plasmacytoid/signet ring cell/diffuse variant being one of the rare amongst these. Till date, no case series has been reported from India, describing this variant. Materials...

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Bibliographic Details
Published in:Indian journal of cancer 2024-04, Vol.61 (2), p.312-316
Main Authors: Gajaria, Pooja Kamlesh, Menon, Santosh, Bakshi, Ganesh, Prakash, Gagan, Joshi, Amit, Murthy, Vedang, Desai, Sangeeta B
Format: Article
Language:English
Subjects:
Analysis
BCG
BCG vaccines
Cancer
Carcinoma
Care and treatment
Development and progression
Diagnosis
Immunohistochemistry
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Summary:Background: Many new morphological variants of urothelial carcinoma of urinary bladder have been described in the literature, plasmacytoid/signet ring cell/diffuse variant being one of the rare amongst these. Till date, no case series has been reported from India, describing this variant. Materials and Methods: We retrospectively analyzed the clinicopathological data of 14 patients diagnosed at our center with plasmacytoid urothelial carcinoma. Results: Seven cases (50%) were pure forms while the remaining 50% of cases had a concurrent conventional urothelial carcinoma component. Immunohistochemistry was performed to rule out other mimickers of this variant. Treatment-related data were available for seven patients, while follow-up was available for nine cases. Conclusion: Overall, plasmacytoid variant of urothelial carcinoma is considered to be an aggressive tumor with poor prognosis. Keywords: Aggressive, cystoprostatectomy, India, plasmacytoid, urinary bladder, urothelial carcinoma
ISSN:0019-509X
1998-4774
DOI:10.4103/ijc.IJC_617_20