Extragonadal germ cell tumor: A rare case in dorsal region

Extragonadal germ cell tumors (GCTs) are a rare group of neoplasms that account for 1-5 of all GCTs. These tumors can present with an unpredictable behavior and clinical manifestations depending on different factors such as histological subtype, anatomical site, and clinical stage. We report the cas...

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Bibliographic Details
Published in:Indian journal of cancer 2024-01, Vol.61 (1), p.124-127
Main Authors: Paparella, Maria Teresa, Eusebi, Laura, Goteri, Gaia, Bartelli, Francesco, Guglielmi, Giuseppe
Format: Article
Language:English
Subjects:
Backache
Cancer
Chemotherapy
Denosumab
Health aspects
Medical colleges
Tumors
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Summary:Extragonadal germ cell tumors (GCTs) are a rare group of neoplasms that account for 1-5 of all GCTs. These tumors can present with an unpredictable behavior and clinical manifestations depending on different factors such as histological subtype, anatomical site, and clinical stage. We report the case of a 43-year-old male patient with a primitive extragonadal seminoma located in the paravertebral dorsal region, an extremely rare site. He presented to our emergency department with a 3-month history of back pain and a 1-week history of fever of unknown origin. Imaging techniques revealed a solid tissue arising from the vertebral bodies of D9-D11 and extending in the paravertebral space. After a bone marrow biopsy and exclusion of testicular seminoma, he was diagnosed with primitive extragonadal seminoma. The patient underwent five cycles of chemotherapy, and the follow-up CT examinations showed a reduction of the mass initially till a complete remission with no evidence of recurrence. Keywords: Chemotherapy, extragonadal, germ cell tumors (GCTs), seminoma
ISSN:0019-509X
1998-4774
DOI:10.4103/ijc.ijc_880_21