Potential Benefits of Physalis minima Stem Water Extract on Bone Health in Ovariectomized Rats: Osteoblast, Osteoclast, and Malondialdehyde Modulation

Around 50% of women over 50 with menopause show osteoporosis symptoms, increasing fracture risk. Estrogen deficiency from menopause affects bone remodeling. Groundcherry (Physalis minima L.) has phytoestrogens. We studied groundcherry stem water extract (GSWE) on femur osteoblasts, osteoclasts, and...

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Published in:Research journal of pharmacy and technology 2024-09, Vol.17 (9), p.4373-4380
Main Authors: Harsachatri, Deasy Ovi, Nugrahenny, Dian, Soeharto, Setyawati, Permatasari, Nur
Format: Article
Language:English
Subjects:
Abdomen
Acids
Alcohol
Antibiotics
Antioxidants
Birth control
Bones
Endocrine therapy
Estrogens
Fractures
Menopause
Oophorectomy
Osteoporosis
Oxidative stress
Womens health
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Summary:Around 50% of women over 50 with menopause show osteoporosis symptoms, increasing fracture risk. Estrogen deficiency from menopause affects bone remodeling. Groundcherry (Physalis minima L.) has phytoestrogens. We studied groundcherry stem water extract (GSWE) on femur osteoblasts, osteoclasts, and malondialdehyde (MDA) in ovariectomized rats. Rats were grouped: sham-operated, 5-week ovariectomized, 9-week ovariectomized, and three GSWE-treated ovariectomized groups (500, 1500, and 2500mg/kgBW for four weeks). Hematoxylin-eosin staining quantified osteoblast and osteoclast numbers (1000x magnification) in right femur bones. Left femur bones were powdered for MDA analysis via thiobarbituric acid reactive substances (TBARS) test. For osteoblasts, 5-week (21.25±0.957) and 9-week ovariectomized rats (22.75±1.708) had reduced (p
ISSN:0974-3618
0974-306X
DOI:10.52711/0974-360X.2024.00676