Contrasting effect of different crowding agents on pseudoknot RNA stability

Pseudoknot (PK) is one of the prevalent and potential targets for drug discovery. It is still difficult to predict PK-forming regions within endogenous RNA transcripts because the intracellular environment consisting of various cellular agents has diverse effects on the structure and stability of nu...

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Bibliographic Details
Published in:Medicinal chemistry research 2024, Vol.33 (11), p.2079-2084
Main Authors: Satpathi, Sagar, Endoh, Tamaki, Sugimoto, Naoki
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Brief Report
Cellular structure
Crowding
Inorganic Chemistry
Medicinal Chemistry
Nucleic acids
Pharmacology/Toxicology
Ribonucleic acid
RNA
Structural stability
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Summary:Pseudoknot (PK) is one of the prevalent and potential targets for drug discovery. It is still difficult to predict PK-forming regions within endogenous RNA transcripts because the intracellular environment consisting of various cellular agents has diverse effects on the structure and stability of nucleic acids. In this study, we have demonstrated the impact of the varied crowding conditions on the structural stability of pseudoknot RNA, emphasizing the distinct stabilities of PK structures depending on the crowding environment.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-024-03293-1