Advances research in porcine enteric coronavirus therapies and antiviral drugs

The porcine enteric coronaviruses (PECs) currently reported include porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV). In the absence of effective treatment, they can cause si...

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Bibliographic Details
Published in:The Veterinary quarterly 2024-12, Vol.44 (1), p.1-49
Main Authors: Liang, Jixiang, Xu, Weihang, Pan, Xiaoming, Han, Shiyun, Zhang, Linwei, Wen, Hao, Ding, Mingyue, Zhang, Wanpo, Peng, Dapeng
Format: Article
Language:English
Subjects:
Alphacoronavirus
Animals
Anorexia
Antiviral agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
antiviral drugs
Coronavirus Infections - drug therapy
Coronavirus Infections - veterinary
Coronavirus Infections - virology
Coronaviruses
COVID-19
Deltacoronavirus - drug effects
Diarrhea
Disease transmission
Drug delivery
Drug development
Drugs
Eating disorders
Economic impact
Gastroenteritis
Health services
Hogs
Neonates
PDCoV
PEDV
Porcine epidemic diarrhea virus - drug effects
Review
SADS-CoV
Sleep and wakefulness
Swine
Swine Diseases - drug therapy
Swine Diseases - virology
TGEV
therapy
Toxicity
Transmissible gastroenteritis
Transmissible gastroenteritis virus - drug effects
Vomiting
Weight loss
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Summary:The porcine enteric coronaviruses (PECs) currently reported include porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), and swine acute diarrhea syndrome coronavirus (SADS-CoV). In the absence of effective treatment, they can cause similar clinical characteristics including weight loss, sleepiness, vomiting, anorexia and fatal diarrhea in neonatal piglets, resulting in significant economic losses to the global pig industry. Although many studies on drugs for treating and combating PECs have been issued. There are still no specific drug targeting PECs and used in clinical production. Therefore, it is necessary to sort out and summarize the research on the treatment and anti PECs drugs, and further development of low toxicity and high efficiency drugs is needed. Here, we review the latest progress of anti PECs drugs, focus on the mechanism of anti PECs reaction of drug components, and try to clarify new strategies for effective control and elimination of PECs. These comprehensive and profound insights will help to further investigate, prevent and control the transmission of PECs infection.
ISSN:0165-2176
1875-5941
1875-5941
DOI:10.1080/01652176.2024.2421299