Framework Nucleic Acid‐Based Selective Cell Catcher for Endogenous Stem Cell Recruitment (Adv. Mater. 50/2024)

Endogenous Stem Cell Recruitment Using the precise programmability of tetrahedral framework nucleic acids (tFNA), Yunfeng Lin, Taoran Tian, and co‐workers introduce a novel strategy for endogenous stem cell enrichment. This strategy employs the MSC‐targeting aptamer Apt19S, optimizing its distributi...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2024-12, Vol.36 (50), p.n/a
Main Authors: Chen, Xingyu, Xu, Ziang, Gao, Yang, Chen, Ye, Yin, Wumeng, Liu, Zhiqiang, Cui, Weitong, Li, Yong, Sun, Jiafei, Yang, Yuting, Ma, Wenjuan, Zhang, Tao, Tian, Taoran, Lin, Yunfeng
Format: Article
Language:English
Subjects:
aptamer 19S
bone repair
hyaluronic acid hydrogel
Nucleic acids
Recruitment
Regeneration (physiology)
stem cell therapy
Stem cells
tetrahedral framework nucleic acid
Tissue engineering
Topology
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Summary:Endogenous Stem Cell Recruitment Using the precise programmability of tetrahedral framework nucleic acids (tFNA), Yunfeng Lin, Taoran Tian, and co‐workers introduce a novel strategy for endogenous stem cell enrichment. This strategy employs the MSC‐targeting aptamer Apt19S, optimizing its distribution and topology on tFNA to address challenges like cellular internalization and low affinity, thereby improving MSC binding and capture efficiency. This acellular, regenerative platform holds great potential for various clinical applications in tissue regeneration. More details can be found in article number 2406118.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202470400