Parathyroidectomy May Cause Remission of Uraemic Tumoral Calcinosis in Haemodialysis Patients

Few cases of uraemic tumoral calcinosis (UTC) have been reported. This study aimed to investigate the clinical efficacy of parathyroidectomy for UTC. Historical clinical data of patients with end-stage renal disease and UTC who underwent parathyroidectomy were analysed. Absorption of metastatic calc...

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Bibliographic Details
Published in:Indian journal of surgery 2024, Vol.86 (Suppl 1), p.59-66
Main Authors: Huang, Haiting, Lu, Jun, Guo, Pengwei, Pang, Jun, Ma, Jing, He, Linlin, You, Yanwu
Format: Article
Language:English
Subjects:
Cardiac Surgery
Hypocalcemia
Medicine
Medicine & Public Health
Neurosurgery
Original Article
Pediatric Surgery
Phosphatase
Phosphorus
Plastic Surgery
Surgery
Thoracic Surgery
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Summary:Few cases of uraemic tumoral calcinosis (UTC) have been reported. This study aimed to investigate the clinical efficacy of parathyroidectomy for UTC. Historical clinical data of patients with end-stage renal disease and UTC who underwent parathyroidectomy were analysed. Absorption of metastatic calcification was compared before and after operation. Changes in intact parathyroid hormone, serum calcium, phosphorus, and alkaline phosphatase levels were analysed before parathyroidectomy and at 1 week and 3, 6, and 12 months after parathyroidectomy. Eight patients met the enrolment criteria (men, 6; mean age, 38.6 SD 10.9 years). Uraemic tumoral calcinosis, which developed 2–8 years after dialysis began, was caused by secondary hyperparathyroidism. Massive calcium deposition was found in the shoulder ( n  = 6), hip ( n  = 3), and elbow ( n  = 2). Four patients had > 2 joints affected, and a single joint was involved for four patients. Seven patients had rapid remission (
ISSN:0972-2068
0973-9793
DOI:10.1007/s12262-022-03283-w