Practical Application of Multivendor MRI‐Based R2 Mapping for Liver Iron Quantification at 1.5T and 3.0T

BackgroundRecent multicenter, multivendor MRI‐based R2* vs. liver iron concentration (LIC) calibrations (i.e., MCMV calibrations) may facilitate broad clinical dissemination of R2*‐based LIC quantification. However, these calibrations are based on a centralized offline R2* reconstruction, and their...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2025-01, Vol.61 (1), p.150-165
Main Authors: Simchick, Gregory, Zhao, Ruiyang, Yuan, Qing, Ghasabeh, Mounes Aliyari, Ruschke, Stefan, Karampinos, Dimitrios C, Harris, David T, Raphael do Vale Souza, Mattison, Ryan J, Jeng, Michael R, Pedrosa, Ivan, Kamel, Ihab R, Vasanawala, Shreyas, Yokoo, Takeshi, Reeder, Scott B, Hernando, Diego
Format: Article
Language:English
Subjects:
Agreements
Calibration
Confidence intervals
Field strength
Health care
Health care facilities
Iron
Liver
Magnetic resonance imaging
Mapping
Reconstruction
Reproducibility
Statistical analysis
Statistical tests
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Summary:BackgroundRecent multicenter, multivendor MRI‐based R2* vs. liver iron concentration (LIC) calibrations (i.e., MCMV calibrations) may facilitate broad clinical dissemination of R2*‐based LIC quantification. However, these calibrations are based on a centralized offline R2* reconstruction, and their applicability with vendor‐provided R2* maps is unclear.PurposeTo determine R2* ranges of agreement between the centralized and three MRI vendors' R2* reconstructions.Study TypeProspective.SubjectsTwo hundred and seven subjects (mean age 37.6 ± 19.6 years; 117 male) with known or suspected iron overload from four academic medical centers.Field Strength/SequenceStandardized multiecho spoiled gradient echo sequence at 1.5 T and 3.0 T for R2* mapping and a multiple spin‐echo sequence at 1.5 T for LIC quantification. MRI vendors: GE Healthcare, Philips Healthcare, and Siemens Healthineers.AssessmentR2* maps were generated using both the centralized and vendor reconstructions, and ranges of agreement were determined. R2*‐LIC linear calibrations were determined for each site, field strength, and reconstruction and compared with the MCMV calibrations.Statistical TestsBland–Altman analysis to determine ranges of agreement. Linear regression, analysis of covariance F tests, and Tukey's multiple comparison testing to assess reproducibility of calibrations across sites and vendors. A P value
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.29401