Concomitant Therapy of Inactivated Enterococcus faecalis CECT7121 with Fluoroquinolones in a Salmonella Enteritidis Murine Sepsis Model

Optimization of existing antimicrobial therapies is a strategy proposed for extending antimicrobial activity and delaying resistance development. This study aimed to assess the effect of inactivated E. faecalis CECT7121 (I-EFCECT7121) in a combined therapy with Enrofloxacin or Ciprofloxacin in a S....

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Bibliographic Details
Published in:Indian journal of microbiology 2024, Vol.64 (4), p.1956-1960
Main Authors: Schofs, Laureano, Sparo, Mónica D., García Allende, Natalia, de Yaniz, María Guadalupe, Confalonieri, Alejandra, Sánchez Bruni, Sergio F.
Format: Article
Language:English
Subjects:
Antimicrobial activity
Antimicrobial agents
Biomedical and Life Sciences
Ciprofloxacin
Combined treatment
Deactivation
Drug development
Enrofloxacin
Fluoroquinolones
Lethal dose
Life Sciences
Medical Microbiology
Microbiology
Salmonella
Salmonella Enteritidis
Sepsis
Short Communications
Survival
Synergism
Therapy
Titration
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Summary:Optimization of existing antimicrobial therapies is a strategy proposed for extending antimicrobial activity and delaying resistance development. This study aimed to assess the effect of inactivated E. faecalis CECT7121 (I-EFCECT7121) in a combined therapy with Enrofloxacin or Ciprofloxacin in a S. Enteritidis murine sepsis model. Firstly, dose titration studies were performed to set up: (a) Salmonella Enteritidis (SE) Lethal dose 99 (LD99) and (b) safety of I-EFCECT7121 (c) I-EFCECT7121 dosage scheme. Then, I-EFCECT7121 in combined therapy with 4 doses (5 mg/kg) per 12 h of CFX and EFX in an LD99 BALB/c infection, were evaluated. Survival rate was monitored for 20 days in order to estimate the treatment success. The efficacy of both drugs was improved by combining them with the inactivated bacteria. However, only a significant increase ( p  
ISSN:0046-8991
0973-7715
DOI:10.1007/s12088-024-01192-y