COMT Val158Met polymorphism protects the impact of a mother's history of childhood trauma on emotional and behavioural problems in preschool children

• Published in: The European journal of neuroscience 2024-12, Vol.60 (12), p.7263-7273
• Main Authors: Janaína Xavier, Clarissa Ribeiro Bastos, Thayane Moreira Marins, Camerini, Laísa, Daniele Behling De Mello, Antunes, Bruna, Luciana de Ávila Quevedo, Mariana Bonati de Matos, Ricardo Tavares Pinheiro, Ghisleni, Gabriele
• Format: Article
• Language: English
• Subjects: Children; Children & youth; Emotional behavior; Gene polymorphism; Life span; Maternal behavior; Mental disorders; Offspring; Trauma
• ISSN: 0953-816X; 1460-9568
• DOI: 10.1111/ejn.16631

Childhood trauma has a well‐established negative impact on mental health outcomes across the lifespan. Cumulative evidence suggests an intergenerational transmission of trauma to descendants. In this way, considering the child's COMT Val158Met (rs4680: G > A) variant, the study aims to investigate the interactive effect of maternal childhood trauma on the emotional/behavioural problems of their offspring in preschoolers age (4–5 and 11 years old) from a population‐based dyad of pregnant adolescent women. The behaviour problems of 310 children were assessed using the Child Behaviour Checklist (CBCL) instrument, and maternal trauma was assessed with the Child Trauma Questionnaire (CTQ) between the 20 to 22° gestational weeks. Maternal childhood trauma increases the risk for all emotional/behavioural problems in the offspring, and no direct association between the child's Val158Met genotypes with emotional/behavioural problems. Interestingly, in moderation analysis adjusted by sex, age and skin colour, children of mothers exposed to childhood trauma, carrying the Val/Met genotype, are less likely to develop externalising (p = .020) and total problems (p = .041) when compared to homozygous (Val/Val and Met/Met). Thus, our findings reinforce evidence on the intergenerational impact of maternal trauma on emotional/behavioural problems and demonstrate that this risk is influenced by the genetic background of the individual, varying according to the functional COMT genotype, which confers a protective profile for the development of externalising and total problems.