High-salt–fat diet: a risk factor for elevated blood pressure associated with dyslipidemia, perturbation in cardio-renal anti-oxidant and pro-inflammatory status in Wistar rats

Background Fatty and salty diets are reported risk factors in the etiology of hypertension, renal and cardiac failure. Oxidative stress and inflammation are biochemical processes in the onset of most diseases. This study sought to evaluate the role of high-salt–fat diet (HS-HFD) on blood pressure (B...

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Bibliographic Details
Published in:Journal of basic & applied zoology 2024-12, Vol.85 (1), p.62
Main Authors: Fadahunsi, Olumide Samuel, Olorunnisola, Olubukola Sinbad
Format: Article
Language:English
Subjects:
Angiotensin
Animal Ecology
Animal Physiology
Biomedical and Life Sciences
Blood pressure
Catalase
Cholesterol
Coronary artery disease
Creatine
Creatine kinase
Creatinine
Dyslipidemia
Embryology
Entomology
Glutathione peroxidase
Glutathione transferase
Heart diseases
High density lipoprotein
Hypertension
Kinases
Life Sciences
Low density lipoprotein
Magnesium
Nitric oxide
Oxidants
Oxidative stress
Parasitology
Physiology
Renal failure
Renal function
Risk factors
Superoxide dismutase
Transforming growth factor-b
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Zoology
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Summary:Background Fatty and salty diets are reported risk factors in the etiology of hypertension, renal and cardiac failure. Oxidative stress and inflammation are biochemical processes in the onset of most diseases. This study sought to evaluate the role of high-salt–fat diet (HS-HFD) on blood pressure (BP), cardio-renal function, redox and inflammatory status. Twelve male Wistar rats were divided into two groups and fed with normal chow and HS-HFD, respectively. Results After 12 weeks, HS-HFD-fed rats showed considerable weight reduction, elevated systolic and diastolic BP. Serum cholesterol and low-density lipoprotein (LDL) were increased, and high-density lipoprotein (HDL) and triacylglycerol levels were significantly ( p  
ISSN:2090-990X
DOI:10.1186/s41936-024-00399-1