Bacteria‐Mediated Bismuth‐Based Nanoparticles Activate Toll‐Like Receptors for Breast Cancer Photothermal Immunotherapy

One of the latest immunotherapeutic strategies involves modulating the tumor microenvironment through Toll‐like receptors (TLRs). However, Toll‐like receptor agonists may induce severe systemic inflammation. Bif@PBi‐R, a bacterial nanomotor is developed with tumor‐targeting properties in this study....

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Bibliographic Details
Published in:Advanced functional materials 2024-12, Vol.34 (51), p.n/a
Main Authors: Xiao, Susu, Feng, Chenqian, Mu, Min, Yu, Wei, Wang, Xiaoxiao, Li, Hui, Chen, Bo, Fan, Rangrang, Chen, Nianyong, Han, Bo, Guo, Gang
Format: Article
Language:English
Subjects:
Bacteria
bifidobacterium
Bismuth
bismuth nanoparticles
Effectiveness
Immune system
Nanomaterials
Nanoparticles
Nanotechnology devices
Photothermal conversion
photothermal immunotherapy
Proteins
Receptors
toll‐like receptors
Tumors
tumor‐targeting
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Summary:One of the latest immunotherapeutic strategies involves modulating the tumor microenvironment through Toll‐like receptors (TLRs). However, Toll‐like receptor agonists may induce severe systemic inflammation. Bif@PBi‐R, a bacterial nanomotor is developed with tumor‐targeting properties in this study. Bismuth‐based nanoparticles loaded with R848 (Bi‐R NPs) are bound to anaerobic bifidobacteria via polydopamine adhesion. Bif@PBi‐R is designed to deliver bismuth‐based nanoparticles carrying R848 specifically to the tumor area to activate anti‐tumor immunotherapy. Bismuth is an excellent nanomaterial for photothermal conversion. Therefore, Bif@PBi‐R not only enhances the efficacy of photothermal therapy to kill tumor cells directly but also boosts the anti‐tumor immune response through its photothermal therapeutic effect. Combining Bif@PBi‐R with 808 nm laser irradiation significantly promoted dendritic cell (DCs) maturation, leading to a potent anti‐tumor effect. In summary, this bacterial nanomotor effectively enhances the efficacy of immunotherapy when combined with photothermal therapy (PTT). A bacterial nanodelivery system is designed with tumor‐targeting properties, Bif@PBi‐R. Bif@PBi‐R specifically delivers bismuth‐based nanoparticles carrying R848 to the tumor region to activate anti‐tumor immunotherapy. Combining Bif@PBi‐R with 808 nm laser irradiation significantly promotes the maturation of dendritic cells (DCs), resulting in a potent anti‐tumor effect.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202410113