Biomaterials enhancing localized cancer therapy activated anti-tumor immunity: a review

Localized cancer therapies such as radiotherapy, phototherapy, and chemotherapy are precise cancer treatment strategies aimed at minimizing systemic side effects. However, cancer metastasis remains the primary cause of mortality among cancer patients in clinical settings, and localized cancer treatm...

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Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-12, Vol.13 (1), p.117-136
Main Authors: Yao, Jipeng, Cui, Zhencun, Zhang, Feifei, Li, Haidong, Tian, Longlong
Format: Article
Language:English
Subjects:
Animals
Anticancer properties
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biomaterials
Biomedical materials
Cancer
Cancer therapies
Chemotherapy
Humans
Immune response
Immunity
Immunotherapy
Metastases
Neoplasms - drug therapy
Neoplasms - immunology
Neoplasms - therapy
Phototherapy
Radiation therapy
Side effects
Tumors
Citations: Items that this one cites
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Summary:Localized cancer therapies such as radiotherapy, phototherapy, and chemotherapy are precise cancer treatment strategies aimed at minimizing systemic side effects. However, cancer metastasis remains the primary cause of mortality among cancer patients in clinical settings, and localized cancer treatments have limited efficacy against metastatic cancer. Therefore, researchers are exploring strategies that combine localized therapy with immunotherapy to activate robust anti-tumor immune responses, thereby eradicating metastatic cancer. Biomaterials, as novel materials, exhibit great potential in biomedical applications and have achieved great progress in clinic translation. This review introduces biomaterials and their applications in research focused on enhancing localized cancer treatment activated anti-tumor immunity. Additionally, the current challenges and future directions of biomaterials are also discussed, providing insights and references for related research. This article reviews the application of biomaterials in combination with immunotherapy to enhance the localized treatment of tumors, along with the current challenges and future development directions in this field.
ISSN:2050-750X
2050-7518
2050-7518
DOI:10.1039/d4tb01995d