Innovations in Metal-Based Nanomedicines to Interfere with the Signaling Communications of Prostate Cancer

Prostate cancer is the second most lethal malignancy in males noticed worldwide. The early stage symptoms of prostate cancer are often unnoticed, which results in delayed diagnosis in the majority of patients, hence resulting in an absence of a chance for timely administration of the most effective...

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Bibliographic Details
Published in:BioNanoScience 2025, Vol.15 (1)
Main Authors: Habeeb, Mohammad, Deepthi, Kolluru Lakshmi, Vengateswaran, Hariharan Thirumalai, Arsey, Shivani, You, Huay Woon, Aher, Kiran Balasaheb
Format: Article
Language:English
Subjects:
Artificial intelligence
Biological and Medical Physics
Biomaterials
Biophysics
Cancer therapies
Cell size
Chemotherapy
Circuits and Systems
Controllability
Drug delivery
Effectiveness
Engineering
Malignancy
Nanotechnology
Physicochemical properties
Prostate cancer
Radiation therapy
Risk factors
Side effects
Signal transduction
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Summary:Prostate cancer is the second most lethal malignancy in males noticed worldwide. The early stage symptoms of prostate cancer are often unnoticed, which results in delayed diagnosis in the majority of patients, hence resulting in an absence of a chance for timely administration of the most effective treatment. Active monitoring, surgery, chemotherapy, hormonal therapy, and radiation therapy are the conventional treatment options for men diagnosed with prostate cancer, but these cells resist various treatments and activate signaling pathways that promote tumor growth resulting in fatality. To mitigate the side effects of chemotherapy on normal cells, emerging nanotechnology can be utilized. Nanomedicines will direct the transport of medications to malignant cells and reduce the harmful effects on systemic circulation. Metal nanoformulations offer advantages over other types of nanoformulations due to their unique properties such as precise size, strong absorbance, photothermal effect, and controllable physicochemical properties. This review delves into metal-based nanotechnology drug delivery techniques, examining their efficacy. We provide a comprehensive overview of risk factors and various nanoformulations for blocking signaling pathways. Furthermore, we analyze current clinical approaches and the integration of artificial intelligence in utilizing metal-based nanomedicines to combat prostate malignancy. Metal-based nanomedicines represent a promising emerging delivery method for effectively diagnosing and treating prostate malignancies. Graphical Abstract
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-024-01723-3