Association of APOE genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage

• Published in: Stroke and vascular neurology 2024-12, p.svn-2024-003477
• Main Authors: Yang, Qiong, Zeng, Xiangzhu, Tang, Lu, Liu, Xiaolu, Xia, Kailin, Gao, Feng, Huang, Xu, Li, Nan, Fan, Dongsheng
• Format: Article
• Language: English
• Subjects: Age; Apolipoproteins; Biomarkers; Blood vessels; Family medical history; Genotype & phenotype; Hemorrhage; Hypertension; Medical imaging; Neuroimaging; Patients; Regression analysis; Variables
• ISSN: 2059-8696
• DOI: 10.1136/svn-2024-003477

We investigated the association of alleles with CT-based cerebral amyloid angiopathy (CAA) markers including subarachnoid extension (SAE) and finger-like projection (FLP). We included patients with acute primary supratentorial intracerebral haemorrhage (ICH) from a multicentre cohort in China. First, the association of with ICH location (lobar vs non-lobar) was evaluated. Next, the relationships of with SAE, FLP, and the coexistence of the two (SAE+FLP) were evaluated. 533 patients with supratentorial ICH were enrolled. Among them were 138 patients with lobar ICH and 395 with non-lobar ICH. Compared with the non-lobar group, ε4 (OR 1.894, 95% CI 1.138 to 3.154, p=0.014) and ε2/ε4 (OR 6.098, 95% CI 1.414 to 26.293, p=0.015) were associated with lobar ICH. With regard to CAA markers, ε2 was associated with SAE (OR 2.109, 95% CI 1.167 to 3.810, p=0.013), ε4 was associated with FLP and SAE+FLP (OR 3.026, 95% CI 1.353 to 6.767, p=0.007; OR 3.514, 95% CI 1.485 to 8.316, p=0.004, respectively) and ε2/ε4 was associated with all three factors (SAH: OR 7.599, 95% CI 1.764 to 32.734, p=0.006; FLP: OR 20.333, 95% CI 3.278 to 126.137, p=0.001; SAE+FLP: OR 30.568, 95% CI 4.460 to 209.503, p