C−X (X=C, O, S, N, B, P) Bond Deuteration and Late‐Stage Applications

Precise deuterium labeling has gained significant attentions owing to the wide applications in organic synthesis, medicinal chemistry, and organic materials. C−C and C‐heteroatom bonds constitute the skeleton of organic molecules. This review summarizes the advancements on C−C and C‐heteroatom bond...

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Bibliographic Details
Published in:European journal of organic chemistry 2024-10, Vol.27 (48), p.n/a
Main Authors: Xu, Hui, Zhang, Yun‐Qian, Dai, Hui‐Xiong
Format: Article
Language:English
Subjects:
C-heteroatom bond deuteration
Chemical bonds
Chemical synthesis
C−C bond Deuteration
Deuteration
Deuterium
Late-stage deuteration
Natural products
Organic chemistry
Organic materials
Photocatalyst
Transition metal catalyst
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Summary:Precise deuterium labeling has gained significant attentions owing to the wide applications in organic synthesis, medicinal chemistry, and organic materials. C−C and C‐heteroatom bonds constitute the skeleton of organic molecules. This review summarizes the advancements on C−C and C‐heteroatom bond deuterations as well as their applications in late‐stage deuterations of natural products and pharmaceutically relevant molecules. Precise deuterium labeling has gained significant attentions owing to the wide applications in organic synthesis, medicinal chemistry and organic materials. C−C and C‐heteroatom bonds constitute the skeleton of organic molecules. This review summarizes the advancements on C−C and C‐heteroatom bond deuterations as well as their late‐stage applications in natural products and pharmaceutically relevant molecules.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202400945