The Evaluation of Anti-Osteoclastic Activity of the Novel Calcium Hydroxide Biodegradable Nanoparticles as an Intracanal Medicament

ABSTRACT Objective: The present investigation looked into PLGA micron-sized particles or NPs, loaded with calcium hydroxide for canal disinfecting processes which have antimicrobial properties, given the significant rejection probabilities related to these kinds of treatments. Methodology: The MIC a...

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Published in:Journal of pharmacy & bioallied science 2024-12, Vol.16 (Suppl 4), p.S3815-S3817
Main Authors: Gautam, Nandita, Bohra, Sonam S. K, Upadhyay, Rutvi, Rakesh, N, Patri, Gaurav, Roshni, R. S, Shetty, Suneeth
Format: Article
Language:English
Subjects:
Analysis
Calcium hydroxide
Cell viability
Confocal microscopy
Diffusion tests
Hydroxides
Minimum inhibitory concentration
Nanoparticles
Osteoclasts
Polylactide-co-glycolide
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Summary:ABSTRACT Objective: The present investigation looked into PLGA micron-sized particles or NPs, loaded with calcium hydroxide for canal disinfecting processes which have antimicrobial properties, given the significant rejection probabilities related to these kinds of treatments. Methodology: The MIC and inhibitory growing zones (n = 5) were found using the broth dilution and agar diffusion tests, accordingly. Employing confocal microscopy and live/dead labelling, cell viability was evaluated (n = 5). ANOVA was used to evaluate, and post hoc analysis came next. Results: Ca(OH)[sub.2] NPs showed a minimum inhibitory concentration of 5 μg/mL for Fn and 10 μg/mL for Pg and Ef (P < 0.001), following a 24-hour incubation period. Conclusion: To sum up, Ca(OH)[sub.2]-contained PLGA NPs show encouraging ability to kill microbes during canal cleaning treatments.z Keywords: Biodegradable, Ca(OH).sub.2, nanoparticles
ISSN:0976-4879
0975-7406
DOI:10.4103/jpbs.jpbs_1288_24