The Effect of Platelet-Rich Fibrin (PRF) in Accelerating Periodontal Regeneration: A Randomized Controlled Clinical Trial

ABSTRACT Background: Regeneration of periodontal tissues is an essential component in treating periodontal disease, and there is an increasing focus on biological agents that might improve the healing process. Materials and Methods: The randomized controlled clinical study included a cohort of 60 in...

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Published in:Journal of pharmacy & bioallied science 2024-12, Vol.16 (Suppl 4), p.S3831-S3833
Main Authors: Dhopte, Ashwini, Devi, Konsam Bidya, Pandaw, KS, Rani, Anamika, Chand, Sachin, Bagde, Hiroj
Format: Article
Language:English
Subjects:
Bone growth
Bone surgery
Clinical trials
Computed tomography
Fibrin
Health aspects
Metronidazole
Periodontal diseases
Periodontitis
Platelets
Postpartum
Postpartum depression
Regeneration
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Summary:ABSTRACT Background: Regeneration of periodontal tissues is an essential component in treating periodontal disease, and there is an increasing focus on biological agents that might improve the healing process. Materials and Methods: The randomized controlled clinical study included a cohort of 60 individuals diagnosed with chronic periodontitis. Each participant was randomly allocated to one of two groups: the experimental group (n = 30), which underwent PRF in combination with traditional open flap debridement (OFD), and the control group (n = 30), which received OFD alone. Clinical criteria such as probing pocket depth (PPD), clinical attachment level (CAL), and bone fill percentage were assessed at baseline and after 6 months. Furthermore, cone-beam computed tomography (CBCT) was used to evaluate bone regrowth radiographically. Results: Following a period of 6 months, the experimental group had a notable decrease in postpartum depression (mean decrease of 4.2 mm) and an increase in central artery ligation (mean increase of 3.5 mm) compared to the control group, which had a mean decrease in postpartum depression of 2.8 mm and a mean increase in central artery ligation of 2.1 mm. The test group had a notably greater proportion of bone fill (45) in comparison to the control group (30). Further radiographic study verified enhanced bone regeneration in the areas treated with PRF. Conclusion: The use of Platelet-Rich Fibrin (PRF) in combination with traditional periodontal surgery greatly expedites the process of periodontal regeneration, as shown by notable enhancements in clinical indicators and bone regeneration. Keywords: Bone regeneration, chronic periodontitis, clinical attachment level, periodontal regeneration, Platelet-Rich Fibrin (PRF), probing pocket depth, randomized controlled trial
ISSN:0976-4879
0975-7406
DOI:10.4103/jpbs.jpbs_1188_24