Antihyperglycemic Potential of Dried Powder Combination of Hygrophila auriculata and Cordia macleodii: In Vivo Study in Sprague Dawley Rats

ABSTRACT Introduction: Hygrophila auriculata (Acanthaceae family) and Cordia macleodii (Boraginaceae family) are two famous Indian plants that had until been unrecognized for their antihyperglycemic effects. This study examined the antihyperglycemic effect of metformin in a rat model of diabetes cau...

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Bibliographic Details
Published in:Journal of pharmacy & bioallied science 2024-12, Vol.16 (Suppl 4), p.S3132-S3135
Main Author: Almutairi, Farooq M
Format: Article
Language:English
Subjects:
Acute toxicity
Bioflavonoids
Blood glucose
Blood levels
Blood sugar
Controlled conditions
Cordia
Diabetes
Diabetes mellitus
Flavones
Flavonoids
Hygrophila auriculata
Medical innovations
Metformin
Oral administration
Powder
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Summary:ABSTRACT Introduction: Hygrophila auriculata (Acanthaceae family) and Cordia macleodii (Boraginaceae family) are two famous Indian plants that had until been unrecognized for their antihyperglycemic effects. This study examined the antihyperglycemic effect of metformin in a rat model of diabetes caused by the alloxan method for dried flower powder of H. auriculata and C. macleodii, both alone and in combination. Materials and Methods: Rat weights ranged from 150-200 g, housed under controlled conditions (25-26°C, 50-55 humidity, 12-hour light/dark cycle) with standard diet and water access. Fresh flowers of H. auriculata and C. macleodii were collected, dried, and powdered. The powders were macerated in methanol, evaporated, and further processed. Acute toxicity was assessed by administering flower powder to rats in doses from 5 mg/kg to 5,000 mg/kg, determining LD50 values per OECD guidelines. Anti-hyperglycemic effects were tested in alloxan-induced diabetic rats, with blood glucose levels measured at intervals after oral administration of the flower powders. The hypoglycemic potential was evaluated using the area under the curve (AUC) method. Results: Five hours after oral treatment, the investigation showed that a mixture of dried flower powder of H. auriculata and C. macleodii significantly reduced blood sugar levels. A key role in modulating the pharmacological action is played by the components derived from plants, including alkaloids and flavonoids. Conclusion: This study will provide light on new avenues for research into the therapeutic treatment of diabetes mellitus via the development of innovative herbal formulations. Keywords: Alloxan, Cordia macleodii, flower, Hygrophila auriculata, hypoglycemic, powder
ISSN:0976-4879
0975-7406
DOI:10.4103/jpbs.jpbs_555_24