Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel

ABSTRACT Introduction: Tridax procumbens (TP) has been used as an anticoagulant and wound healer. Known by other names as Tridax daisy or coatbuttons, TP belongs to flowering plant species of Asteraceae family. The current study is conducted to analyze the anti-inflammatory and antioxidant activity...

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Published in:Journal of pharmacy & bioallied science 2024-12, Vol.16 (Suppl 4), p.S4081-S4084
Main Authors: Nandita, R, Jeevitha, M, Gurumoorthy, Kaarthikeyan, Shanmugham, Rajeshkumar, Ravichandran, Sudarsan, Raj, Kethiswar
Format: Article
Language:English
Subjects:
Albumin
Analysis
Anti-inflammatory agents
Anti-inflammatory drugs
Antioxidants
Bovine serum albumin
Chitosan
Denaturation
Ethylenediaminetetraacetic acid
Flowering
Free radicals
Hydrogen peroxide
Hydroxyl radicals
Inflammation
Leaves
Medicine, Botanic
Medicine, Herbal
Oxidative stress
Plant extracts
Proteins
Tridax
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container_end_page S4084
container_issue Suppl 4
container_start_page S4081
container_title Journal of pharmacy & bioallied science
container_volume 16
creator Nandita, R
Jeevitha, M
Gurumoorthy, Kaarthikeyan
Shanmugham, Rajeshkumar
Ravichandran, Sudarsan
Raj, Kethiswar
description ABSTRACT Introduction: Tridax procumbens (TP) has been used as an anticoagulant and wound healer. Known by other names as Tridax daisy or coatbuttons, TP belongs to flowering plant species of Asteraceae family. The current study is conducted to analyze the anti-inflammatory and antioxidant activity of TP leaves extract-based chitosan (TPC) gel. Materials and Methods: Anti-inflammatory activity of TPC gel was assessed by bovine serum albumin (BSA) denaturation assay and egg albumin (EA) denaturation assay. Free radical scavenging activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and hydroxyl radical scavenging (H[sub.2]O[sub.2]) assay. Results: Both BSA and EA assay showed that the TPC gel (test gel) demonstrated maximum inhibition at 50 μL concentration and lowest inhibition at 10 μL similar to commercially available gel. The antioxidant activity assays revealed that both standard and the test gel exhibited high inhibitory percentage at all tested concentrations. Conclusion: The anti-inflammatory and antioxidant assay results demonstrate that the investigated compounds, notably TP leaves extract-based chitosan gel, have the potential to be effective agents in moderating oxidative stress and lowering inflammation. Keywords: Anti-inflammatory, antioxidant, innovative, Tridax procumbens, wound-healing
doi_str_mv 10.4103/jpbs.jpbs_1439_24
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Known by other names as Tridax daisy or coatbuttons, TP belongs to flowering plant species of Asteraceae family. The current study is conducted to analyze the anti-inflammatory and antioxidant activity of TP leaves extract-based chitosan (TPC) gel. Materials and Methods: Anti-inflammatory activity of TPC gel was assessed by bovine serum albumin (BSA) denaturation assay and egg albumin (EA) denaturation assay. Free radical scavenging activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and hydroxyl radical scavenging (H[sub.2]O[sub.2]) assay. Results: Both BSA and EA assay showed that the TPC gel (test gel) demonstrated maximum inhibition at 50 μL concentration and lowest inhibition at 10 μL similar to commercially available gel. The antioxidant activity assays revealed that both standard and the test gel exhibited high inhibitory percentage at all tested concentrations. Conclusion: The anti-inflammatory and antioxidant assay results demonstrate that the investigated compounds, notably TP leaves extract-based chitosan gel, have the potential to be effective agents in moderating oxidative stress and lowering inflammation. Keywords: Anti-inflammatory, antioxidant, innovative, Tridax procumbens, wound-healing</description><identifier>ISSN: 0976-4879</identifier><identifier>EISSN: 0975-7406</identifier><identifier>DOI: 10.4103/jpbs.jpbs_1439_24</identifier><language>eng</language><publisher>Mumbai: Medknow Publications and Media Pvt. 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Known by other names as Tridax daisy or coatbuttons, TP belongs to flowering plant species of Asteraceae family. The current study is conducted to analyze the anti-inflammatory and antioxidant activity of TP leaves extract-based chitosan (TPC) gel. Materials and Methods: Anti-inflammatory activity of TPC gel was assessed by bovine serum albumin (BSA) denaturation assay and egg albumin (EA) denaturation assay. Free radical scavenging activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and hydroxyl radical scavenging (H[sub.2]O[sub.2]) assay. Results: Both BSA and EA assay showed that the TPC gel (test gel) demonstrated maximum inhibition at 50 μL concentration and lowest inhibition at 10 μL similar to commercially available gel. The antioxidant activity assays revealed that both standard and the test gel exhibited high inhibitory percentage at all tested concentrations. Conclusion: The anti-inflammatory and antioxidant assay results demonstrate that the investigated compounds, notably TP leaves extract-based chitosan gel, have the potential to be effective agents in moderating oxidative stress and lowering inflammation. 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Known by other names as Tridax daisy or coatbuttons, TP belongs to flowering plant species of Asteraceae family. The current study is conducted to analyze the anti-inflammatory and antioxidant activity of TP leaves extract-based chitosan (TPC) gel. Materials and Methods: Anti-inflammatory activity of TPC gel was assessed by bovine serum albumin (BSA) denaturation assay and egg albumin (EA) denaturation assay. Free radical scavenging activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay and hydroxyl radical scavenging (H[sub.2]O[sub.2]) assay. Results: Both BSA and EA assay showed that the TPC gel (test gel) demonstrated maximum inhibition at 50 μL concentration and lowest inhibition at 10 μL similar to commercially available gel. The antioxidant activity assays revealed that both standard and the test gel exhibited high inhibitory percentage at all tested concentrations. Conclusion: The anti-inflammatory and antioxidant assay results demonstrate that the investigated compounds, notably TP leaves extract-based chitosan gel, have the potential to be effective agents in moderating oxidative stress and lowering inflammation. Keywords: Anti-inflammatory, antioxidant, innovative, Tridax procumbens, wound-healing</abstract><cop>Mumbai</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><doi>10.4103/jpbs.jpbs_1439_24</doi></addata></record>
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subjects Albumin
Analysis
Anti-inflammatory agents
Anti-inflammatory drugs
Antioxidants
Bovine serum albumin
Chitosan
Denaturation
Ethylenediaminetetraacetic acid
Flowering
Free radicals
Hydrogen peroxide
Hydroxyl radicals
Inflammation
Leaves
Medicine, Botanic
Medicine, Herbal
Oxidative stress
Plant extracts
Proteins
Tridax
title Anti-Inflammatory Activity and Free Radical Scavenging Activity of Tridax Procumbens Leaves-Based Chitosan Gel
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